The effect of environmental tobacco smoke on eczema and allergic sensitization in children
The effect of environmental tobacco smoke on eczema and allergic sensitization in children
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DOI：
10.1111/j.1365-2133.2004.05710.x
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发表时间：
2004-01-01
影响因子：
10.3
通讯作者：
Ring, J
中科院分区：
文献类型：
--
作者：
Krämer, U;Lemmen, CH;Ring, J
背景环境烟草烟雾（ETS）对儿童气道疾病的负面影响是众所周知的。是否有一个效果，对特应性eczema是不明确的，目的是确定影响ETS对特应性湿疹，过敏性致敏和过敏性气道疾病在1669 school beginners.Methods过敏性相关的健康结果的患病率进行了评估问卷调查，皮肤科检查，皮肤点刺试验和特异性免疫球蛋白E测量。暴露评估的基础上测量可替宁[表示为可替宁肌酸比（CCR）]在现场尿液样本（n = 1220）连同问卷调查和访谈数据的吸烟行为的parents.Results在总研究组，过敏性湿疹的患病率诊断检查显着相关与尿CCR值。CCR每增加100 ng mg（-1）计算的比值比（OR）和95%置信区间（CI）为1.97（95% CI 1.23-3.16）。根据问卷调查数据，皮肤表现的患病率以及哮喘、喘息和花粉热病史与ETS暴露呈正相关，但无显著相关性。当将遗传易感儿童（定义为父母存在特应性）与父母无特应性的儿童进行比较时，第一组中过敏结局变量的OR通常较高。在易感儿童组，显着的关联与尿CCR被发现对屋尘螨过敏致敏皮肤点刺试验（OR 3.10，95%CI 1.63-5.90）。结论儿童是在发展的特应性湿疹时，暴露于ETS和遗传易感的儿童是在发展对屋尘螨过敏的风险较高。
Background The negative impact of environmental tobacco smoke (ETS) on airway diseases in children is well known. Whether there is an effect on atopic eczema is not clear.Objectives To determine the impact of ETS on atopic eczema, allergic sensitization and allergic airway diseases in 1669 school beginners.Methods The prevalence of atopy-related health outcomes was assessed by questionnaire, dermatological examination, skin prick testing and specific immunoglobulin E measurement. Exposure assessments were based on measurement of cotinine [expressed as cotinine to creatine ratio (CCR)] in spot urine samples (n = 1220) together with questionnaire and interview data on smoking behaviour of the parents.Results In the total study group, prevalence of atopic eczema diagnosed on examination was significantly associated with urinary CCR values. The odds ratio (OR) and 95% confidence interval (CI), calculated for an increase of 100 ng mg(-1) CCR was 1.97 (95% CI 1.23-3.16). The prevalence of skin manifestations according to questionnaire data as well as a history of asthma, wheezing, and hay fever were positively although not significantly associated with ETS exposure. When genetically predisposed children (defined by the presence of parental atopy) were compared with children whose parents had no atopy, the ORs of allergic outcome variables were generally higher in the first group. In the group of predisposed children, significant associations with urinary CCR were found for allergic sensitization against house dust mites as measured by skin prick test (OR 3.10, 95% CI 1.63-5.90).Conclusions Children are at a higher risk of developing an atopic eczema when exposed to ETS and genetically predisposed children are at higher risk of developing a sensitization against house dust mites.