Case Study of Anti-1-Amino-3-F-18 Fluorocyclobutane-1-Carboxylic Acid (Anti-[F-18] FACBC) to Guide Prostate Cancer Radiotherapy Target Design
Case Study of Anti-1-Amino-3-F-18 Fluorocyclobutane-1-Carboxylic Acid (Anti-[F-18] FACBC) to Guide Prostate Cancer Radiotherapy Target Design
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抗 1-氨基-3-F-18 氟环丁烷-1-羧酸 (抗-[F-18] FACBC) 指导前列腺癌放疗靶点设计的案例研究
DOI：
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发表时间：
2009
影响因子：
10.6
通讯作者：
D. Schuster
中科院分区：
文献类型：
--
作者：
A. Jani;T. Fox;D. Whitaker;D. Schuster
Purpose of the Report: Anti-1-amino-3-F-18 fluorocyclobutane-1-carboxylic acid (FACBC) is a novel radiotracer, which has shown some promise for use with positron emission tomography (PET)/computed tomography (CT) for visualizing prostate cancer. Here we describe a case of a prostate cancer patient who underwent radiation treatment and had an FACBC scan obtained as part of a pilot study. Methods: We explored the potential impact of FACBC on treatment planning. We registered the FACBC acquisition with the PET/CT, which required a simple translation. Then, we did a deformable image registration of the PET/CT with the planning CT—this process allowed the FACBC-defined gross tumor volume (GTVFACBC) to be projected into the planning CT. An intensity-modulated radiotherapy (IMRT) plan (plan A) not including GTVFACBC (with final dose to 81.0 Gy) was generated, as was an IMRT plan including the GTVFACBC to a final dose of 86.4 Gy (plan B). Target coverage and normal tissue dose volume histogram (DVH) endpoints were tabulated. Results: In this particular patient, bladder constraints could not be met on any plan due to anatomic limitations. However, the impact on the rectal DVH could be assessed, and inclusion of the GTVFACBC did permit rectal DVH constraints to be met in plan B while maintaining target coverage and inhomogeneity constraints. Conclusion: In our test case, it was feasible to use FACBC to guide IMRT, and highlights the role of deformable image registration of the PET/CT with the planning CT. These findings can guide future studies incorporating FACBC into treatment planning.
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DOI：
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发表时间：
2006
期刊：
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子：
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作者：
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DOI：
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发表时间：
2004-10-01
影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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DOI：
10.1053/srao.2002.00000
发表时间：
2002
期刊：
Seminars in radiation oncology.
影响因子：
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作者：
Zelefsky,MichaelJ;Fuks,Zvi;Leibel,StevenA
通讯作者：
Leibel,StevenA
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DOI：
--
发表时间：
2004
期刊：
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子：
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作者：
Larson,StevenM;Morris,Michael;Gunther,Ilonka;Beattie,Brad;Humm,JohnL;Akhurst,TimothyA;Finn,RonaldD;Erdi,Yusuf;Pentlow,Keith;Dyke,Jon;Squire,Olivia;Bornmann,William;McCarthy,Timothy;Welch,Michael;Scher,Howard
通讯作者：
Scher,Howard