Cause of death in autopsy-confirmed dementia disorders
Cause of death in autopsy-confirmed dementia disorders
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DOI：
10.1111/ene.14450
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发表时间：
2020-08-31
影响因子：
5.1
通讯作者：
Englund, E. M.
中科院分区：
文献类型：
--
作者：
Degerskar, A. N. W.;Englund, E. M.
背景和目的痴呆症易导致致命的并发症，并降低预期寿命。因此，对痴呆症终末期疾病的更深入了解可以改善这些患者的治疗和护理。方法对207例临床诊断为神经认知障碍/痴呆的死亡个体和200例同龄神经认知健康个体的尸检报告进行研究。比较痴呆组和对照组的尸检结果，尤其是死亡原因。结果痴呆人群的前2位死因是肺炎（34.3%）和急性心肌梗死（30.4%）。这一结果与对照组不同，在对照组中，急性心肌梗死（42.5%）占死亡事件的大多数，其次是循环衰竭（12.5%）。痴呆症亚型的主要死亡原因各不相同。此外，在阿尔茨海默病中，肺炎在严重/晚期病例中更常见，而急性心肌梗死在轻度病例中更常见。结论痴呆与同龄普通人群的死亡原因不同，痴呆亚型之间的死亡原因也不同。阿尔茨海默病的严重程度反映在不同的最终条件。这些发现与痴呆症的最后阶段护理和治疗有关。
Background and purpose Dementia disorders predispose for lethal complications and decrease life expectancy. A more profound knowledge regarding end-stage conditions in dementia could therefore ameliorate treatment and care of these patients. Methods Autopsy reports on 207 deceased individuals with clinically diagnosed neurocognitive disorder/dementia and on 200 neurocognitively healthy individuals of the same age range were studied. Autopsy results, especially cause of death, were compared between the dementia and the control groups. Results The two most frequent causes of death in the dementia population were pneumonia (34.3%) and acute myocardial infarction (30.4%). This result differed from that of the control group, in which acute myocardial infarction (42.5%) accounted for most events of deaths, followed by circulatory failure (12.5%). The leading cause of death varied amongst dementia subtypes. Further, in Alzheimer's disease pneumonia was more frequent in severe/advanced cases whilst acute myocardial infarction was more common in milder cases. Conclusions Cause of death differed between the demented and the general population of the same age and between subtypes of dementia. Alzheimer's disease severity was reflected in different final conditions. The findings have relevance for the final stage care and treatment in dementia disorders.