Molecularly imprinted polymers.
Molecularly imprinted polymers.
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DOI：
10.1007/978-0-306-48584-8_10
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发表时间：
2004
影响因子：
--
通讯作者：
K. Ulubayram
中科院分区：
文献类型：
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作者：
K. Ulubayram
分子印迹聚合物(MIP)1-4是高度稳定的聚合物模具，对各种分子具有选择性的分子识别性能。MIPS由在模板(印迹)分子存在下合成的高度交联的聚合物组成。除去模板后，留下一个空腔，该空腔保留了对模板的亲和力和选择性。在优化的条件下，一些分子印迹聚合物(如抗体模拟物)具有与自然产生的识别系统(如单抗和受体2)相媲美的高选择性和亲和力常数。此外，它们独特的稳定性优于天然生物分子；而且它们坚固耐用，价格低廉。它们的制备简单，易于适应不同的实际应用，使其在化学、制药和生物技术工业中非常有用。
Molecularly imprinted polymers (MIPs)1–4are highly stable polymeric molds that possess selective molecular recognition properties for various kinds of molecules. MIPs consist of highly crosslinked polymers that are synthesized in the presence of a template (imprint) molecule. After removal of template, a cavity is left, which retains affinity and selectivity for the template. Some of MIPs (such as antibody mimics), under optimized conditions, have high selectivities and afffiinity constants comparable with naturally occuring recognition systems such as monoclonal antibodies and receptors2. In addition, their unique stability is superior to that demonstrated by natural biomolecules; and they are robust and inexpensive. The simplicity of their preparation and the ease of adaptation to different practical applications make them very useful for chemical, pharmaceutical, and biotechnological industries.