Quantitative correspondence between the in vivo and in vitro activity of teratogenic agents.
Quantitative correspondence between the in vivo and in vitro activity of teratogenic agents.
复制标题
致畸剂的体内和体外活性之间的定量对应关系。
DOI：
10.1073/pnas.79.6.2056
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发表时间：
1982
影响因子：
11.1
通讯作者：
Nichinson,BB
中科院分区：
文献类型：
--
作者：
Braun,AG;Buckner,CA;Emerson,DJ;Nichinson,BB
We have tested 74 teratogenic and 28 nonteratogenic agents in a recently developed in vitro teratogen assay system. The assay identifies teratogens by their ability to inhibit attachment of ascites tumor cells to plastic surfaces coated with concanavalin A. There is a qualitative agreement between in vivo animal data and in vitro activity for 81 of the 102 agents (79%). Quantitative analysis shows a highly significant correlation coefficient of 0.69 between the inhibitory in vitro dose and the lowest reported teratogenic dose for 54 of the 60 inhibitory teratogens. The doses analyzed ranged over 5 orders of magnitude. We interpret these results to mean that attachment inhibition in concert with other, complementary, in vitro assay systems can become a useful method for the assessment of the teratogenic potential of environmental agents.
影响因子：
8.8
作者：
A. Craig
通讯作者：
A. Craig