Associations of urinary 6-sulfatoxymelatonin with biomarkers related to cardiovascular disease in Japanese women.
Associations of urinary 6-sulfatoxymelatonin with biomarkers related to cardiovascular disease in Japanese women.
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DOI：
10.1016/j.metabol.2011.05.021
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发表时间：
2012
期刊：
影响因子：
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通讯作者：
Takako Masue;K. Wada;M. Hayashi;N. Takeda;K. Yasuda;T. Deguchi;C. Nagata
中科院分区：
文献类型：
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作者：
Takako Masue;K. Wada;M. Hayashi;N. Takeda;K. Yasuda;T. Deguchi;C. Nagata
褪黑素对心血管疾病（CVD）的潜在预防作用仍然是假设的。目前还没有研究评估内源性褪黑激素与心血管疾病相关的血液生物标志物之间的关系。本研究的目的是检查内源性褪黑激素水平与各种已建立的CVD风险血液生物标志物之间的关系，包括白细胞（WBC）计数和血浆脂质浓度、同型半胱氨酸、尿酸（UA）和高敏c反应蛋白（hs-CRP）。这项横断面研究包括181名日本妇女，她们在2005年3月至2006年3月期间参加了一家综合医院提供的健康检查项目。所有的研究对象都回答了一份自我管理的问卷，并测量了体重、身高和血压。所有受试者均采集空腹静脉血和首次空腹晨尿。在控制了年龄、体重指数、绝经状态、吸烟状态、饮食、睡眠习惯和运动后，尿中褪黑素的主要代谢物——尿中6-亚硫代氧褪黑素（aMT6s）与白细胞计数、UA和hs-CRP之间存在显著的负相关（r分别为- 0.19、- 0.21和- 0.24）。尿amt6与血脂和同型半胱氨酸之间无显著相关性。这些数据表明，尿aMT6s水平与CVD的独立危险因素（如WBC、UA和hs-CRP）呈负相关。内源性褪黑素可能与心血管疾病的风险有关。
Melatonin's potential preventive effect against cardiovascular disease (CVD) remains hypothetical. No study has evaluated the relationships between endogenous melatonin and the established blood biomarkers related to CVD. The objective of the present study is to examine the association between the endogenous melatonin level and various established blood biomarkers of risk of CVD, including white blood cell (WBC) count and plasma concentrations of lipids, homocysteine, uric acid (UA), and high-sensitivity C-reactive protein (hs-CRP). This cross-sectional study included 181 Japanese women who attended a health checkup program provided by a general hospital between March 2005 and March 2006. All study subjects responded to a self-administered questionnaire and were measured for weight, height, and blood pressure. Venous fasting blood and first-void morning urine were obtained from all subjects. Statistically significant inverse correlations were observed between urinary 6-sulfatoxymelatonin (aMT6s), the major metabolite of melatonin in urine, and WBC count, UA, and hs-CRP after controlling for age, body mass index, menopausal status, smoking status, diet, sleeping habits, and exercise (r = −0.19, −0.21, and −0.24, respectively). There were no significant correlations between urinary aMT6s and plasma lipids and homocysteine. These data suggested that the urinary aMT6s level was inversely associated with established independent risk factors for CVD, such as WBC, UA, and hs-CRP. Endogenous melatonin may have implications for the risk of CVD.