Expression status of folate receptor α is significantly correlated with prognosis in non-small-cell lung cancers
Expression status of folate receptor α is significantly correlated with prognosis in non-small-cell lung cancers
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DOI：
10.1245/s10434-007-9755-3
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发表时间：
2008-03-01
影响因子：
3.7
通讯作者：
Miyahara, Ryo
中科院分区：
文献类型：
--
作者：
Iwakiri, Shotaro;Sonobe, Makoto;Miyahara, Ryo
背景：评估叶酸受体α (FOLR1)和/或叶酸载体（RFC1）表达减少在完全切除的非小细胞肺癌（NSCLC）中的预后价值。叶酸受体α (FOLR1)和/或叶酸载体（RFC1）表达减少是叶酸转运蛋白的特征。方法：定量检测非小细胞肺癌手术标本中FOLR1和RFC1的基因表达。共纳入2003年1月至2004年6月连续119例患者。结果：在腺癌中，吸烟者和男性患者FOLR1基因表达下调（P = 0.006和P < 0.001）。FOLR1在高分化、早期P期、pT1、pN0、EGFR突变、p53野生型癌症患者中的表达值显著高于低分化、晚期P期、p2 -4、pN1-3、EGFR野生型、p53突变患者（P < 0.001、P < 0.001、P = 0.002、P < 0.001、P = 0.023）。在鳞状细胞癌中，pN1-3患者的FOLR1表达值显著高于pN0患者（P = 0.037）。高表达folr1患者的3年生存率和无病生存率（分别为94.7%和75.4%）显著高于低表达folr1患者（分别为80.9%和60.8%）（P = 0.008和P = 0.038）。多因素分析证实FOLR1高表达是预测预后良好的独立且显著的因素（P = 0.043）。结论：高水平的FOLR1似乎与肺腺癌患者更好的预后相关。
Background: To evaluate the prognostic value of folate receptor alpha (FOLR1) and/or reduced folate carrier (RFC1) expression, which are well-characterized folate transporters, in completely resected non-small-cell lung cancer (NSCLC).Methods: We quantitatively examined gene expression of FOLR1 and RFC1 in surgical specimens resected from NSCLC patients. A total of 119 consecutive patients from January 2003 to June 2004 were included.Results: In adenocarcinoma, the FOLR1 gene expression was downregulated in smokers and male patients (P = 0.006 and P < 0.001, respectively). In addition, FOLR1 expression values in patients with well-differentiated, early p-stage, pT1, pN0, EGFR mutant, and p53 wild-type cancers were significantly higher than those for poorly differentiated, advanced p-stage, pT2-4, pN1-3, EGFR wild-type, and p53 mutant (P < 0.001, P < 0.001, P < 0.001, P = 0.002, P < 0.001 and P = 0.023, respectively). In squamous cell carcinoma, FOLR1 expression values in patients with pN1-3 was significantly higher than those with pN0 (P = 0.037). Moreover, the 3-year survival rate and disease-free survival rate of high-FOLR1-expressing patients (94.7% and 75.4%) were significantly higher than those of low-FOLR1-expressing patients (80.9% and 60.8%) (P = 0.008 and P = 0.038). A multivariate analysis confirmed that high FOLR1 expression was an independent and significant factor predicting a favorable prognosis (P = 0.043).Conclusions: Higher levels of FOLR1 appear to be associated with better prognoses for patients with lung adenocarcinomas.