Synthesis, characterization, and morphology studies of biodegradable amphiphilic poly[(R)-3-hydroxybutyrate]-alt-poly(ethylene glycol) multiblock copolymers.
Synthesis, characterization, and morphology studies of biodegradable amphiphilic poly[(R)-3-hydroxybutyrate]-alt-poly(ethylene glycol) multiblock copolymers.
复制标题
DOI：
10.1021/bm060675f
复制
发表时间：
2006-10
影响因子：
6.2
通讯作者：
Xu Li;K. Liu;Jun Li;E. Tan;L. M. Chan;C. Lim;S. Goh
中科院分区：
文献类型：
--
作者：
Xu Li;K. Liu;Jun Li;E. Tan;L. M. Chan;C. Lim;S. Goh
以聚[(R)-3-羟基丁酸酯]（PHB）为可生物降解疏水嵌段，聚乙二醇（PEG）为亲水嵌段（PHB- PEG）为偶联反应，成功合成了新型可生物降解的两亲交替嵌段共聚物。利用凝胶渗透色谱、H核磁共振和傅里叶变换红外光谱对其化学结构进行了表征。差示扫描量热法（DSC）分析表明，PHB-alt-PEG嵌段共聚物中除了短嵌段（M(n) 600）外，PHB嵌段和PEG嵌段均可结晶形成独立的结晶相。然而，由于相互干扰，PHB和PEG的结晶相的熔融转变都比相应的纯PHB和PEG的结晶相温度更低，结晶度更低。用x射线衍射研究了PHB嵌段和PEG嵌段的结晶行为，结果与DSC研究结果吻合较好。利用原子力显微镜观察了在云母上自旋涂覆的PHB-alt-PEG嵌段共聚物薄膜的表面形貌，表明其形成了横向规则的片层状表面图案。静态水接触角测试表明，随着聚乙二醇嵌段含量的增加，这些自旋涂覆薄膜的表面亲水性增加。
Novel biodegradable amphiphilic alternating block copolymers based on poly[(R)-3-hydroxybutyrate] (PHB) as biodegradable and hydrophobic block and poly(ethylene glycol) (PEG) as hydrophilic block (PHB-alt-PEG) were successfully synthesized through coupling reaction. Their chemical structures have been characterized by using gel permeation chromatography, (1)H nuclear magnetic resonance, and Fourier transform infrared spectroscopy. Differential scanning calorimetry (DSC) analysis revealed that both PHB and PEG blocks in PHB-alt-PEG block copolymers can crystallize to form separate crystalline phase except in those with a short PEG block (M(n) 600) only PHB crystalline phase has been observed. However, due to the mutual interference from each other, the melting transition of both PHB and PEG crystalline phases shifted to lower temperature with lower crystallinity in comparison with corresponding pure PHB and PEG. The crystallization behavior of PHB block and PEG block has also been studied by X-ray diffraction, and the results were in good agreement with those deduced from DSC study. The surface morphologies of PHB-alt-PEG block copolymer thin films spin-coated on mica have been visualized by atomic force microscopy with tapping mode, indicating formation of laterally regular lamellar surface patterns. Static water contact angle measurement revealed that surface hydrophilicity of these spin-coated thin films increases with increasing PEG block content.