Analysis of the retinal nerve fiber layer after indocyanine green-assisted vitrectomy for idiopathic macular holes
Analysis of the retinal nerve fiber layer after indocyanine green-assisted vitrectomy for idiopathic macular holes
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DOI：
10.1016/j.ophtha.2005.10.046
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发表时间：
2006-02-01
期刊：
影响因子：
13.7
通讯作者：
Sakamoto, T
中科院分区：
文献类型：
--
作者：
Yamashita, T;Uemura, A;Sakamoto, T
目的：采用光学相干断层扫描（OCT）分析吲哚青绿辅助玻璃体切除术治疗特发性黄斑裂孔后有或无视野（VF）缺损的眼的视网膜神经纤维层（RNFL）厚度，并探讨术后VF缺损与RNFL损伤之间的关系。设计：回顾性干预病例系列。参与者：2001年1月至2003年3月期间接受玻璃体切除术的32例特发性黄斑裂孔患者的34只眼纳入本研究。根据术后VF缺损的发生率和术中使用吲哚菁绿色进行内界膜剥离，将患眼分为3组：吲哚菁绿辅助玻璃体切除术后有VF缺损的11只眼（第1组），使用吲哚菁绿色后无VF缺损的9只眼（第2组），第3组（n = 14）为玻璃体切除术后不使用吲哚菁绿色的无VF缺损眼OCT测量（上级、低级、鼻侧、颞侧）。主要结果测量：视盘周围视网膜神经纤维层厚度。第1组上级、鼻侧、下侧4个象限中有3个象限的RNFL平均厚度显著小于第2、3组相应象限的厚度（P < 0.01）。在颞象限中，第1组和第3组之间存在显著差异（P = 0.02），但第1组和第2组之间无显著差异。结论：吲哚菁绿辅助玻璃体切割术治疗黄斑裂孔后VF缺损眼的RNFL厚度明显减少，提示术后VF缺损可能与吲哚菁绿色的使用有关。
Purpose: To analyze retinal nerve fiber layer (RNFL) thickness in eyes with or without visual field (VF) defects after indocyanine green-assisted vitrectomy for idiopathic macular holes using optical coherence tomography (OCT) and to investigate the relationship between postoperative VF defects and RNFL damage.Design: Retrospective interventional case series.Participants: Thirty-four eyes of 32 patients with idiopathic macular holes that underwent vitrectomy between January 2001 and March 2003 were included in this study. Eyes were divided into 3 groups according to the occurrence of postoperative VF defects and the use of indocyanine green for internal limiting membrane peeling during surgery: 11 eyes with VF defects after indocyanine green-assisted vitrectomy (group 1), 9 eyes without VF defects despite the use of indocyanine green (group 2), and 14 eyes without VF defects that underwent vitrectomy without indocyanine green (group 3).Methods: Retinal nerve fiber layer thickness in each of 4 quadrants (superior, inferior, nasal, temporal) was measured with OCT.Main Outcome Measure: Retinal nerve fiber layer thickness around the optic disc.Results: The mean RNFL thickness in 3 of 4 quadrants (superior, nasal, inferior) in group 1 was significantly less than that in the corresponding quadrant in groups 2 and 3 (P < 0.01). In the temporal quadrant, there was a significant difference between groups 1 and 3 (P = 0.02), but not between groups 1 and 2. The RNFL thickness in group 1 was significantly less in 3 quadrants in operated eyes than in fellow eyes (P < 0.05).Conclusions: The RNFL thickness was reduced in eyes with VF defects after indocyanine green-assisted vitrectomy for macular holes, suggesting that the postoperative VF defects may have been caused by RNFL damage relating to the use of indocyanine green.