The receptor proteins: pivotal roles in selective autophagy
The receptor proteins: pivotal roles in selective autophagy
复制标题
受体蛋白：选择性自噬中的关键作用
DOI：
10.1093/abbs/gmv055
复制
发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Cao Ya
中科院分区：
文献类型：
--
作者：
Xu Zhijie;Yang Lifang;Xu San;Zhang Zhibao;Cao Ya
自噬是一种高度调节的多步骤生物学过程，其中细胞在代谢、蛋白毒性或其他应激下通过将功能失调的细胞器和/或错误折叠/多聚泛素化的蛋白质经由称为自噬体的专门结构穿梭到溶酶体进行降解来去除它们。虽然自噬通常被认为是一个非选择性的过程，但越来越多的证据表明，它也可以选择性地降解特定的目标货物。这些选择性的目标包括蛋白质，线粒体，甚至入侵的细菌。自噬适配器的发现和表征，如p62/Sequestosome 1（SQSTM 1）和BRCA 1基因1的邻居（NBR 1），为选择性自噬提供了机制上的见解。这些受体都能够作为货物受体降解泛素化底物。本文主要综述了在选择性自噬调控中起重要作用的关键受体蛋白的最新研究成果。
Autophagy is a highly regulated and multistep biological process whereby cells under metabolic, proteotoxic, or other stresses remove dysfunctional organelles and/or misfolded/polyubiquitinated proteins by shuttling them via specialized structures called autophagosomes to the lysosome for degradation. Although autophagy is generally considered to be a non-selective process, accumulating evidence suggests that it can also selectively degrade specific target cargoes. These selective targets include proteins, mitochondria, and even invading bacteria. The discovery and characterization of autophagic adapters, such as p62/Sequestosome 1 (SQSTM1) and Neighbor of BRCA1 gene 1 (NBR1), have provided mechanistic insights into selective autophagy. These receptors are all able to act as cargo receptors for the degradation of ubiquitinated substrates. This review mainly summarizes the most up-to-date findings regarding the key receptor proteins that play important roles in regulating selective autophagy.