Characterizing Thalamo-Cortical Disturbances in Schizophrenia and Bipolar Illness
Characterizing Thalamo-Cortical Disturbances in Schizophrenia and Bipolar Illness
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DOI：
10.1093/cercor/bht165
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发表时间：
2014-12-01
期刊：
影响因子：
3.7
通讯作者：
Glahn, David C.
中科院分区：
文献类型：
--
作者：
Anticevic, Alan;Cole, Michael W.;Glahn, David C.
精神分裂症是一种破坏性的神经精神综合征，与可能涉及大规模丘脑-皮质系统的分布式大脑连接障碍有关。对精神分裂症丘脑连接的不完整描述限制了我们对其与症状和诊断的关系的理解，这些症状和诊断具有共同的临床表现，例如双相情感障碍，这可能存在于一个谱中。使用静息态功能磁共振成像，我们通过以下方式描述了90名精神分裂症患者与90名匹配对照者的丘脑连接：（1）受试者特定解剖学定义的丘脑种子;（2）解剖学和数据驱动的聚类分析丘脑内的连接障碍;以及（3）机器学习通过丘脑连接对精神分裂症和47名双相情感障碍患者和47名匹配对照进行诊断隶属度分类。精神分裂症分析显示功能相关的障碍：丘脑与双侧感觉运动皮层的过度连接，这可以预测症状，但丘脑与前额叶-纹状体-小脑区域的连接不足，可能反映了感觉门控和自上而下的控制障碍。聚类显示，这种连接障碍在与前额皮质紧密相连的丘脑核团中尤为突出。分类和交叉诊断的结果表明，丘脑连接障碍可能是一个神经标志物的障碍，在诊断。目前的研究结果，使用迄今为止最大的精神分裂症和双相神经影像学样本之一，告知大规模丘脑-皮质系统的基本理解，并提供有关严重精神疾病中其干扰的复杂性质的重要线索。
Schizophrenia is a devastating neuropsychiatric syndrome associated with distributed brain dysconnectivity that may involve large-scale thalamo-cortical systems. Incomplete characterization of thalamic connectivity in schizophrenia limits our understanding of its relationship to symptoms and to diagnoses with shared clinical presentation, such as bipolar illness, which may exist on a spectrum. Using resting-state functional magnetic resonance imaging, we characterized thalamic connectivity in 90 schizophrenia patients versus 90 matched controls via: (1) Subject-specific anatomically defined thalamic seeds; (2) anatomical and data-driven clustering to assay within-thalamus dysconnectivity; and (3) machine learning to classify diagnostic membership via thalamic connectivity for schizophrenia and for 47 bipolar patients and 47 matched controls. Schizophrenia analyses revealed functionally related disturbances: Thalamic over-connectivity with bilateral sensory-motor cortices, which predicted symptoms, but thalamic under-connectivity with prefrontal-striatal-cerebellar regions relative to controls, possibly reflective of sensory gating and top-down control disturbances. Clustering revealed that this dysconnectivity was prominent for thalamic nuclei densely connected with the prefrontal cortex. Classification and cross-diagnostic results suggest that thalamic dysconnectivity may be a neural marker for disturbances across diagnoses. Present findings, using one of the largest schizophrenia and bipolar neuroimaging samples to date, inform basic understanding of large-scale thalamo-cortical systems and provide vital clues about the complex nature of its disturbances in severe mental illness.