Jamestown Canyon Virus Disease in the United States-2000-2013
Jamestown Canyon Virus Disease in the United States-2000-2013
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DOI：
10.4269/ajtmh.15-0196
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发表时间：
2015-08-01
影响因子：
3.3
通讯作者：
Staples, J. Erin
中科院分区：
文献类型：
--
作者：
Pastula, Daniel M.;Johnson, Diep K. Hoang;Staples, J. Erin
詹姆斯敦峡谷病毒(JCV)是一种由蚊子传播的加州血清群正丁型病毒，可导致急性发热性疾病、脑膜炎或脑膜脑炎。我们描述了2000-2013年间在美国发生的JCV疾病病例的流行病学和临床特征。JCV病病例被定义为具有最近JCV感染的实验室证据的人的急性疾病。在2000-2013年间，我们在13个州的居民中确认了31例JCV疾病。中位年龄48岁(10-69岁)，男性21例(68%)。脑膜脑炎11例(35%)，脑膜炎6例(19%)，无神经系统受累发热7例(23%)，临床症状不明7例(23%)。15人(48%)住院治疗，无死亡病例。卫生保健提供者和公共卫生官员应在病毒性脑膜炎和脑炎的鉴别诊断中考虑JCV病，获取适当的标本进行检测，并向公共卫生当局报告病例。
Jamestown Canyon virus (JCV) is a mosquito-borne orthobunyavirus in the California serogroup that can cause an acute febrile illness, meningitis, or meningoencephalitis. We describe epidemiologic and clinical features for JCV disease cases occurring in the United States during 2000-2013. A case of JCV disease was defined as an acute illness in a person with laboratory evidence of a recent JCV infection. During 2000-2013, we identified 31 cases of JCV disease in residents of 13 states. The median age was 48 years (range, 10-69) and 21(68%) were male. Eleven (35%) case patients had meningoencephalitis, 6 (19%) meningitis, 7 (23%) fever without neurologic involvement, and 7 (23%) had an unknown clinical syndrome. Fifteen (48%) were hospitalized and there were no deaths. Health-care providers and public health officials should consider JCV disease in the differential diagnoses of viral meningitis and encephalitis, obtain appropriate specimens for testing, and report cases to public health authorities.