Two-hour glucose is a better risk predictor for incident coronary heart disease and cardiovascular mortality than fasting glucose
Two-hour glucose is a better risk predictor for incident coronary heart disease and cardiovascular mortality than fasting glucose
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DOI：
10.1053/euhj.2001.3113
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发表时间：
2002-08-01
影响因子：
39.3
通讯作者：
Tuomilehto, J
中科院分区：
文献类型：
--
作者：
Qiao, Q;Pyörälä, K;Tuomilehto, J
目的：评估75 g葡萄糖负荷后空腹和2小时血糖对冠心病发病率和心血管死亡率的预测价值。方法与结果对6766名年龄在30-89岁之间的芬兰人进行了7-10年的随访。与葡萄糖浓度升高相关的危险比在研究中是均匀的。多因素Cox回归分析显示，对数转换后2小时血糖增加一个标准差，冠心病发病率的危险比为1-17 (95% CI 1.05-1.30)，心血管死亡率的危险比为1.22（1.09-1.37）。空腹血糖分别为1.05（0.94-1.17）和1.13（1.01-1.25）。在基于空腹血糖的模型中纳入2小时葡萄糖显著改善了预测（冠心病发病率P < 0.005，心血管死亡率P < 0.025），而空腹血糖并没有为最初基于2小时葡萄糖的模型增加显著信息（两种事件的P均为0.0.10）。结论在无糖尿病史的受试者中，2小时血糖与冠心病发病率和心血管道德的关系是分级和独立的。我们的研究结果表明，在评估未来心血管疾病事件的风险方面，2小时葡萄糖优于空腹葡萄糖。(C) 2002年由Elsevier Science Ltd代表欧洲心脏病学会出版。
Alms To assess the predictive value of fasting and 2-h glucose after a 75 g glucose load, with regard to incidence of coronary heart disease and cardiovascular mortality.Methods and Results 6766 subjects from five Finnish cohorts aged 30-89 years were followed up for 7-10 years. Hazards ratios associated with increasing glucose concentrations were homogeneous over studies. Multivariate Cox regression analyses showed that the hazards ratio for one standard deviation increase in 2-h glucose after logarithmic transformation was 1-17 (95% CI 1.05-1.30) for coronary heart disease incidence and 1.22 (1.09-1.37) for cardiovascular mortality. For fasting glucose, they were 1.05 (0.94-1.17) and 1.13 (1.01-1.25), respectively. Inclusion of 2-h glucose in the model based on fasting glucose significantly improved the prediction (P < 0.005 for coronary heart disease incidence and P < 0.025 for cardiovascular mortality), whereas fasting glucose did not add significant information to the model initially based on 2-h glucose (P > 0.10 for both events).Conclusion In subjects without a prior history of diabetes the association of 2-h glucose with coronary heart disease incidence and cardiovascular morality is graded and independent. The results of our study indicate that 2-h glucose is superior to fasting glucose in assessing the risk of future cardiovascular disease events. (C) 2002 Published by Elsevier Science Ltd on behalf of The European Society of Cardiology.