Liprotein(a) Phenotypes in Japanese Children: A Cohort Study
Liprotein(a) Phenotypes in Japanese Children: A Cohort Study
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日本儿童的脂蛋白 (a) 表型：一项队列研究
DOI：
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Keijiro Yabuta
中科院分区：
文献类型：
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作者：
Osamu Arisaka;S. Fujiwara;Noriko Miyake;Hiroshi Mokuno;Keijiro Yabuta
血清脂蛋白（a）[Lp（a）]浓度升高已被证明与过早动脉粥样硬化引起的心血管疾病有关。然而，Lp（a）表型与这些疾病的发展之间的关系在很大程度上尚未探索。我们分析了一个社区269名8 - 13岁日本儿童血清Lp（a）表型的人群频率。根据载脂蛋白（a）[apo（a）]电泳迁移率的不同，Lp（a）分为7种单带和相应的双带表型。Lp（a）浓度频率分布偏向低水平，均值± SD为15.5 ± 18.0 mg/dl，中位数为11.0 mg/dl。Lp（a）表型频率显示，双带表型表达频率（55%）高于单带表型表达频率（44%），代表低分子量apo（a）的表型频率非常低（2%）。双带表达受试者的平均血清Lp（a）浓度高于单带表型受试者（20.1 ± 19.9vs.10.5 ± 15.9mg/dl，p < 0.01）。儿童Lp（a）表型的这些发现似乎与另一项研究中日本成人的结果不同;与预期相反，在儿童中发现的主要Lp（a）表型是那些经常与成人心血管疾病相关的表型。因此，推测在向成年过渡期间Lp（a）表型保持不变的儿童可能表现出对心血管疾病的易感性增加，尽管营养对Lp（a）表型的影响不可忽视。
Elevated serum lipoprotein(a) [Lp(a)] concentrations have been demonstrated to be associated with cardiovascular diseases due to premature atherosclerosis. However, the association of Lp(a) phenotypes with the development of these diseases remains largely unexplored.We analyzed the population‐based frequencies of serum Lp(a) phenotypes in 269 Japanese children aged 8‐13 years in one community. According to the different apolipoprotein(a) [apo(a)] electrophoretic mobilities, Lp(a) was classified into seven single‐band and respective double‐band phenotypes. Each individual expressed a single (homozygotic) or a double band (heterozygotic).The serum Lp(a) concentration frequency distribution was skewed toward lower levels with a mean ± SD of 15.5 ± 18.0 mg/dl and a median of 11.0 mg/dl. The Lp(a) phenotype frequencies revealed that the frequency of double‐band phenotype expression (55%) was higher than that of single bands (44%) and that the frequency of phenotypes representative of low molecular weight apo(a) was very low (2%). The mean serum Lp(a) concentration of the double‐band‐expressing subjects was higher than that of subjects with the single‐band phenotype (20.1 ± 19.9 vs. 10.5 ± 15.9 mg/dl, p < 0.01).These findings of Lp(a) phenotypes in children seemed to differ from those in Japanese adults in another study; contrary to expectation, the predominant Lp(a) phenotypes found in children were those frequently associated with cardiovascular diseases in adults. Thus, it is speculated that children whose Lp(a) phenotypes remain unchanged during the transition to adulthood may show an increased susceptibility to cardiovascular disease, although the nutritional effects on the Lp(a) phenotypes cannot be neglected.
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影响因子：
15.9
作者：
BOERWINKLE, E;LEFFERT, CC;HOBBS, HH
通讯作者：
HOBBS, HH
墨西哥裔美国人载脂蛋白 (a) 大小和脂蛋白 (a) 浓度之间多模式关系的遗传基础。
影响因子：
5.3
作者：
Rainwater,DL
通讯作者：
Rainwater,DL
患有冠状动脉疾病的家族中脂蛋白（a）水平的遗传变异几乎完全由载脂蛋白（a）基因位点决定。
影响因子：
9.8
作者：
DeMeester,CA;Bu,X;Gray,RJ;Lusis,AJ;Rotter,JI
通讯作者：
Rotter,JI
人载脂蛋白[a]的多态性：遗传及其分子量与脂蛋白血浆水平的关系[a]。
影响因子：
6.5
作者：
Gaubatz,JW;Ghanem,KI;GuevaraJr,J;Nava,ML;Patsch,W;Morrisett,JD
通讯作者：
Morrisett,JD