TrkB-deficient mice show diminished phase shifts of the circadian activity rhythm in response to light
TrkB-deficient mice show diminished phase shifts of the circadian activity rhythm in response to light
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DOI：
10.1016/j.neulet.2004.12.023
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发表时间：
2005-04-22
影响因子：
2.5
通讯作者：
Earnest, DJ
中科院分区：
文献类型：
--
作者：
Allen, GC;Qu, XY;Earnest, DJ
脑源性神经营养因子（BDNF）与下丘脑视交叉上核（SCN）生物钟对光相移效应的昼夜节律敏感性的机制有关。在本研究中，我们通过确定 TrkB 基因靶向突变小鼠的光相移作用是否受损，研究了 BDNF 的同源受体（TrkB 酪氨酸激酶）在 SCN 时钟光调节中的作用。与野生型同窝小鼠相比，杂合 TrkB 突变小鼠 (trkB(+/-)) 显示这种神经营养素受体的 SCN 和皮质水平显着降低，同时伴随主观夜间光诱导相移幅度的降低。这些结果提供了进一步的证据，表明 BDNF 介导的 TrkB 受体信号传导是 SCN 对光反应的门控及其对昼夜节律的相移影响的重要过程。 (c) 2004 Elsevier Ireland Ltd. 保留所有权利。
Brain-derived neurotrophic factor (BDNF) has been implicated in the mechanism underlying the circadian sensitivity of the clock in the hypothalamic suprachiasmatic nucleus (SCN) to the phase-shifting effects of light. In the present study, we examined the role of the cognate receptor for BDNF, the TrkB tyrosine kinase, in the photic regulation of the SCN clock by determining whether the phase-shifting action of light is impaired in mice with targeted mutation of the TrkB gene. In comparison with wild-type littermates, heterozygous TrkB mutant mice (trkB(+/-)) showed marked reductions in SCN and cortical levels of this neurotrophin receptor that were accompanied by decreases in the amplitude of light-induced phase shifts during the subjective night. These results provide further evidence indicating that BDNF-mediated signaling through the TrkB receptor is an important process in the gating of SCN responses to light and its phase-shifting effects on circadian rhythms. (c) 2004 Elsevier Ireland Ltd. All rights reserved.