Current concepts on the molecular pathology of non-small cell lung carcinoma.
Current concepts on the molecular pathology of non-small cell lung carcinoma.
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DOI：
10.1053/j.semdp.2014.06.008
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发表时间：
2014-07
影响因子：
2.3
通讯作者：
Wistuba II
中科院分区：
文献类型：
--
作者：
Fujimoto J;Wistuba II
对非小细胞肺癌（NSCLC）复杂生物学的理解，特别是通过突变，易位和扩增激活癌基因的最新进展，为这种疾病提供了新的治疗靶点，并允许识别NSCLC肿瘤的子集，主要是腺癌组织学，具有独特的分子特征，可以预测对靶向治疗的反应。使用肿瘤组织和细胞学标本识别特定的遗传和分子靶向异常，然后向靶点施用特定的抑制剂，是个性化肺癌治疗的基础。在这种新的模式下，肺癌的精确病理诊断以及正确处理组织和细胞学样本进行分子检测的作用变得越来越重要。这些变化给病理学家提出了许多新的挑战，使其能够将常规组织病理学分析和分子检测充分整合到临床病理学实践中，以进行肿瘤诊断和随后选择最合适的治疗。
Recent advances in the understanding of the complex biology of non-small cell lung carcinoma (NSCLC), particularly activation of oncogenes by mutation, translocation and amplification, have provided new treatment targets for this disease, and allowed the identification of subsets of NSCLC tumors, mostly with adenocarcinoma histology, having unique molecular profiles that can predict response to targeted therapy. The identification of a specific genetic and molecular targetable abnormalities using tumor tissue and cytology specimens followed by the administration of a specific inhibitor to the target, are the basis of personalized lung cancer treatment. In this new paradigm, the role of a precise pathology diagnosis of lung cancer and the proper handling of tissue and cytology samples for molecular testing is becoming increasingly important. These changes have posed multiple new challenges for pathologists to adequately integrate routine histopathology analysis and molecular testing into the clinical pathology practice for tumor diagnosis and subsequent selection of the most appropriate therapy.
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影响因子：
8.8
作者：
通讯作者：
--
影响因子：
28.2
作者：
Hammerman PS;Sos ML;Ramos AH;Xu C;Dutt A;Zhou W;Brace LE;Woods BA;Lin W;Zhang J;Deng X;Lim SM;Heynck S;Peifer M;Simard JR;Lawrence MS;Onofrio RC;Salvesen HB;Seidel D;Zander T;Heuckmann JM;Soltermann A;Moch H;Koker M;Leenders F;Gabler F;Querings S;Ansén S;Brambilla E;Brambilla C;Lorimier P;Brustugun OT;Helland A;Petersen I;Clement JH;Groen H;Timens W;Sietsma H;Stoelben E;Wolf J;Beer DG;Tsao MS;Hanna M;Hatton C;Eck MJ;Janne PA;Johnson BE;Winckler W;Greulich H;Bass AJ;Cho J;Rauh D;Gray NS;Wong KK;Haura EB;Thomas RK;Meyerson M
通讯作者：
Meyerson M
影响因子：
3.7
作者：
Gu TL;Deng X;Huang F;Tucker M;Crosby K;Rimkunas V;Wang Y;Deng G;Zhu L;Tan Z;Hu Y;Wu C;Nardone J;MacNeill J;Ren J;Reeves C;Innocenti G;Norris B;Yuan J;Yu J;Haack H;Shen B;Peng C;Li H;Zhou X;Liu X;Rush J;Comb MJ
通讯作者：
Comb MJ
DOI：
10.1073/pnas.0710370104
发表时间：
2007-12-26
影响因子：
11.1
作者：
Bean, James;Brennan, Cameron;Pao, William
通讯作者：
Pao, William
影响因子：
5.3
作者：
Jin, Guang;Kim, Min Jung;Park, Jae Yong
通讯作者：
Park, Jae Yong