SELECTIVE IGA DEFICIENCY - PRESENTATION OF 30 CASES AND REVIEW OF LITERATURE
SELECTIVE IGA DEFICIENCY - PRESENTATION OF 30 CASES AND REVIEW OF LITERATURE
复制标题
DOI：
10.1097/00005792-197105000-00004
复制
发表时间：
1971-01-01
期刊：
影响因子：
1.6
通讯作者：
HONG, R
中科院分区：
文献类型：
--
作者：
AMMANN, AJ;HONG, R
由于 IgA 是某些局部分泌物的主要免疫球蛋白成分 (80, 81)（即从直接接触外部环境的器官获得的分泌物），因此预计对 IgA 缺乏状态的研究将有助于了解局部免疫系统。然而，选择性 IgA 缺乏的临床意义存在争议。一些报告描述了临床正常个体中的这种缺陷 (39, 67)，而其他更大的系列报告描述了与重大疾病相关的选择性 IgA 缺陷 (16, 17, 47, 89)。本综述的目的是基于对文献中 150 多个病例的回顾以及我们对 30 名患者的经验，对选择性 IgA 缺乏状态的范围进行广泛分析。选择性IgA缺乏症定义如下：1——血清IgA低于0.05 mg/ml。 2 – 不缺乏其他免疫球蛋白，例如 IgG、IgM、IgD 或 IgE。 3-正常的细胞免疫。 4–正常的体液抗体产生。我们的研究中获得的数据与文献中描述的患者回顾的相关性可以进一步阐明选择性 IgA 缺乏和疾病的相互关系。
Since IgA is the major immunoglobulin component of certain local secretions (80, 81),(ie those obtained from organs having direct access to the external environment) it was anticipated that the study of IgA deficient states would lead to an understanding of the local immune system. However, controversy exists as to the clinical significance of selective IgA deficiency. Some reports describe this deficiency in clinically normal individuals (39, 67) while other larger series describe selective IgA deficiency in association with significant disease (16, 17, 47, 89). It is the purpose of this review to present an extensive analysis of the spectrum of selective IgA deficiency states based upon a review of over 150 cases from the literature and our experience with 30 patients. Selective IgA deficiency is defined as follows:1–less than 0.05 mg/ml serum IgA. 2–no deficiency of other immunoglobulins, eg IgG, IgM, IgD, or IgE. 3–normal cellular immunity. 4–normal humoral antibody production. Correlation of the data obtained in our studies with a review of patients described in the literature permits further elucidation of the interrelationships of selective IgA deficiency and disease.