Distinct histopathological characteristics in colorectal submucosal invasive carcinoma arising in sessile serrated adenoma/polyp and conventional tubular adenoma
Distinct histopathological characteristics in colorectal submucosal invasive carcinoma arising in sessile serrated adenoma/polyp and conventional tubular adenoma
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DOI：
10.1007/s00428-017-2234-8
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发表时间：
2018-03-01
期刊：
影响因子：
3.5
通讯作者：
Watanabe, Sumio
中科院分区：
文献类型：
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作者：
Murakami, Takashi;Mitomi, Hiroyuki;Watanabe, Sumio
无蒂锯齿状腺瘤/息肉（SSA/P）是一种罕见的恶性肿瘤，其组织病理学特征尚未完全阐明。为了探讨其特点，我们回顾性分析了40例伴有SSA/P的粘膜下浸润性癌（CA-SSA/P），并将其与129例粘膜下浸润性癌伴传统管状腺瘤（CA-AD）进行比较。我们还进行了 hMLH1 免疫染色。 CA-SSA/Ps 显着小于 CA-ADs (P < 0.001)。组织学上，CA-SSA/P 和 CA-AD 中均以高分化至中分化腺癌为主。两组之间的浸润深度没有发现显着差异。然而，CA-SSA/Ps (30%) 比 CA-ADs (13%; P = 0.028) 更常见淋巴管侵犯，淋巴结转移也是如此 (CA-SSA/Ps, 28%; CA-ADs, 7%; P = 0.011)。此外，CA-SSA/Ps 中的粘液成分和锯齿状结构（30% 和 63%）显着高于 CA-ADs（5% 和 18%；分别为 P < 0.001）。肿瘤浸润淋巴细胞和克罗恩样炎症反应在 CA-SSA/P 中也更常见（70% 和 30%），而在 CA-AD 中（31% 和 9%；P
The histopathological characteristics of colorectal submucosal invasive carcinoma arising in sessile serrated adenoma/polyp (SSA/P), a rare malignant tumour, have not yet been fully elucidated. To investigate the features of such, we retrospectively analysed 40 submucosal invasive carcinomas with SSA/P (CA-SSA/P) and compared them to 129 cases of submucosal invasive carcinoma with conventional tubular adenoma (CA-AD). We additionally performed hMLH1 immunostaining. CA-SSA/Ps were significantly smaller than CA-ADs (P < 0.001). Histologically, well to moderately differentiated adenocarcinoma was predominant in both CA-SSA/Ps and CA-ADs. No significant differences in depth of invasion were found between the two groups. However, lymphatic invasion was more often found in CA-SSA/Ps (30%) than in CA-ADs (13%; P = 0.028), as was lymph node metastasis (CA-SSA/Ps, 28%; CA-ADs, 7%; P = 0.011). Furthermore, mucinous component and serrated architecture were significantly more frequent in CA-SSA/Ps (30 and 63%) than in CA-ADs (5 and 18%; P < 0.001, respectively). Tumour-infiltrating lymphocytes and Crohn-like inflammatory reaction were also more frequently found in CA-SSA/Ps (70 and 30%) than in CA-ADs (31 and 9%; P