ROLE OF RED BLOOD CORPUSCLES IN REGULATION OF RENAL BLOOD FLOW AND GLOMERULAR FILTRATION RATE
ROLE OF RED BLOOD CORPUSCLES IN REGULATION OF RENAL BLOOD FLOW AND GLOMERULAR FILTRATION RATE
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DOI：
10.1152/ajplegacy.1956.185.2.399
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发表时间：
1956-01-01
影响因子：
--
通讯作者：
PAPPENHEIMER, JR
中科院分区：
文献类型：
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作者：
KINTER, WB;PAPPENHEIMER, JR
在麻醉猫呼吸氧气的急性实验中，测量了肾血流量作为动脉红细胞浓度的函数。当动脉红细胞浓度在20-55%范围内变化时，肾血流量仅发生轻微变化，尽管在玻璃管或灌注的后腿中测量的血液粘度变化很大。然而，当红细胞浓度逐渐降低到20%以下时，血流量（在恒压下测量）大大增加，尽管在这个细胞浓度范围内血液粘度变化很小。在正常和非常低的动脉红细胞浓度下，测量肾血流量和肾小球滤过率（肌酐清除率）作为动脉压的函数。在低红细胞浓度下，肾脏血流和滤过率的自动调节部分或全部被取消。细胞恢复后，自动调节功能恢复。实验结果可以用肾血流动力学的细胞分离理论来解释(1)。根据这一理论，肾血流量和肾小球滤过率在很大程度上受小叶间动脉中红细胞与血浆分离效率的控制。许多先前归因于传入和传出小动脉阻力差异变化的观察结果，同样可以用细胞分离理论来解释。
Renal blood flow was measured as a function of arterial red cell concentration in acute experiments on anesthetized cats breathing oxygen. Renal blood flow changed only slightly when the arterial red cell concentration was varied over the range 20–55%, despite large changes in the viscosity of blood as measured in a glass tube or in a perfused hindleg. When the red cell concentration was progressively reduced below 20%, however, the blood flow (measured at constant pressure) increased greatly, despite the fact that blood viscosity changes very little in this range of cell concentrations. Renal blood flow and glomerular filtration rate (creatinine clearance) were measured as a function of arterial pressure at normal and at very low arterial red cell concentrations. Autoregulation of both renal blood flow and filtration rate was partly or wholly abolished at low red cell concentrations. Autoregulation returned when cells were restored. The experimental results are explicable in terms of the cell-separation theory of renal hemodynamics (1). According to this theory the renal blood flow and glomerular filtration rate are largely controlled by the efficiency of separation of red cells from plasma in the interlobular arteries. Many observations which were previously attributed to differential changes in afferent and efferent arteriolar resistance can be equally well accounted for in terms of the cell-separation theory.