Caenorhabditis elegans as an emerging model for studying the basic biology of obesity
Caenorhabditis elegans as an emerging model for studying the basic biology of obesity
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DOI：
10.1242/dmm.001933
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发表时间：
2009-05-01
影响因子：
4.3
通讯作者：
Ashrafi, Kaveh
中科院分区：
文献类型：
--
作者：
Jones, Kevin T.;Ashrafi, Kaveh
肥胖及其相关疾病的健康问题凸显了了解调节脂质代谢的成分和途径的必要性。由于能量平衡是由一个复杂的调控网络维持的，因此使用像秀丽隐杆线虫这样强大的遗传模型可以补充哺乳动物生理学的研究，为识别基因和剖析复杂的调控回路提供新的机会。许多控制人体新陈代谢的核心成分在蠕虫中是保守的。虽然对线虫脂质代谢的研究还相对较新，但在追踪调节脂肪储存的遗传途径和开发探索代谢调节和食物感觉的不同方面的测定方法方面已经取得了很大进展。这个模型系统很有希望帮助梳理出维持适当能量平衡的复杂基因网络。
The health problem of obesity and its related disorders highlights the need for understanding the components and pathways that regulate lipid metabolism. Because energy balance is maintained by a complex regulatory network, the use of a powerful genetic model like C elegans can complement studies on mammalian physiology by offering new opportunities to identify genes and dissect complicated regulatory circuits. Many of the components that are central to governing human metabolism are conserved in the worm. Although the study of lipid metabolism in C elegans is still relatively young, much progress has already been made in tracing out genetic pathways that regulate fat storage and in developing assays to explore different aspects of metabolic regulation and food sensation. This model system holds great promise for helping tease apart the complicated network of genes that maintain a proper energy balance.