The effects of unilateral eighth nerve block on fictive VOR in the turtle.
The effects of unilateral eighth nerve block on fictive VOR in the turtle.
复制标题
单侧第八神经阻滞对乌龟虚拟 VOR 的影响。
DOI：
10.1016/j.brainres.2006.03.121
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发表时间：
2006
期刊：
影响因子：
2.9
通讯作者：
Ariel,Michael
中科院分区：
文献类型：
--
作者：
Jones,MichaelS;Ariel,Michael
在水平正弦运动时，记录了来自完整半规管输入的离体龟脑干制备物的动眼神经、滑车神经或展外神经对的多单元活动。左动眼神经、右滑车神经和右展展神经的反应与左头部速度基本一致，对侧神经的反应与右头部速度基本一致。观察右前庭神经切开或注射利多卡因（0.5% 1 ~ 2 μL）的效果。神经阻滞引起了右动眼神经和左滑车神经诱发反应的显著相移，其中（向右）控制反应被对左桌子运动的较小幅度反应所取代。这种“相位反转”反应在外展神经记录中定义不清。频率分析表明，这种活动相对于各自对侧神经阻滞后的反应提前，而对侧神经的反应相对于阻滞前的对照提前。在低频（~ 0.1 Hz）时相位差最大（~ 10°），在1 Hz时无统计学差异。通过消除右侧nVIII阻滞后左侧迷宫的单个通道输入，进一步研究了相位反转反应，这表明垂直通道传入的激活是这种活动的来源。
Multiunit activity during horizontal sinusoidal motion was recorded from pairs of oculomotor, trochlear, or abducens nerves of an in vitro turtle brainstem preparation that received inputs from intact semicircular canals. Responses of left oculomotor, right trochlear and right abducens nerves were approximately aligned with leftward head velocity, and that of the respective contralateral nerves were in-phase with rightward velocity. We examined the effect of sectioning or injecting lidocaine (1–2 μL of 0.5%) into the right vestibular nerve. Nerve block caused a striking phase shift in the evoked response of right oculomotor and left trochlear nerves, in which (rightward) control responses were replaced by a smaller-amplitude response to leftward table motion. Such “phase-reversed” responses were poorly defined in abducens nerve recordings. Frequency analysis demonstrated that this activity was advanced in phase relative to post-block responses of the respective contralateral nerves, which were in turn phase-advanced relative to pre-block controls. Phase differences were largest (∼10°) at low frequencies (∼0.1 Hz) and statistically absent at 1 Hz. The phase-reversed responses were further investigated by eliminating individual canal input from the left labyrinth following right nVIII block, which indicated that the activation of the vertical canal afferents is the source of this activity.