Subclinical Brain Injury Caused by H5N1 Influenza Virus Infection
Subclinical Brain Injury Caused by H5N1 Influenza Virus Infection
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DOI：
10.1128/jvi.00239-11
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发表时间：
2011-05-01
影响因子：
5.4
通讯作者：
Kawaoka, Yoshihiro
中科院分区：
文献类型：
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作者：
Shinya, Kyoko;Makino, Akiko;Kawaoka, Yoshihiro
尽管H5N1甲型流感病毒可引起全身性感染，但其嗜神经性和对中枢神经系统的长期影响尚不完全清楚。我们在雪貂模型中评估了h5n1病毒对中枢神经系统的入侵及其长期影响。H5N1病毒引起非化脓性脑炎，持续3个月，无神经症状。此外，另一种H5N1病毒引起非化脓性血管炎并脑出血。对病毒在大脑中的分布进行三维分析，发现嗅觉系统是侵入大脑的主要途径。病毒在上呼吸道的有效生长可能因此促进病毒侵入大脑。
Although H5N1 influenza A viruses can cause systemic infection, their neurotropism and long-term effects on the central nervous system (CNS) are not fully understood. We assessed H5N1viral invasion of the CNS and its long-term effects in a ferret model. An H5N1 virus caused nonsuppurative encephalitis, which lasted for 3 months without neurologic signs. Further, another H5N1 virus caused nonsuppurative vasculitis with brain hemorrhage. Three-dimensional analysis of viral distribution in the brain identified the olfactory system as a major route for brain invasion. The efficient growth of virus in the upper respiratory tract may thus facilitate viral brain invasion.