Adult BMI and fat distribution but not height amplify the effect of low birthweight on insulin resistance and increased blood pressure in 20-year-old South Africans
Adult BMI and fat distribution but not height amplify the effect of low birthweight on insulin resistance and increased blood pressure in 20-year-old South Africans
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DOI：
10.1007/s00125-005-1748-9
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发表时间：
2005-06-01
期刊：
影响因子：
8.2
通讯作者：
Hales, CN
中科院分区：
文献类型：
--
作者：
Levitt, NS;Lambert, EV;Hales, CN
我们研究了低出生体重和成人慢性心血管代谢疾病之间的关联是否仅取决于出生体重，或与BMI，脂肪堆积（一般或腹部）或南非年轻成年人身高的相互作用。测量足月出生的20岁儿童（n=132）的血压（BP）、血脂、葡萄糖耐量、胰岛素敏感性和分泌（稳态模型），这些儿童的出生体重等于或低于第10百分位数（胎龄体重不足[乌法]）或在第25和第75百分位数之间（胎龄体重适当，[AFA]）。BMI、腰围、体脂百分比和身高的性别特异性中位数测量值定义了当前的人体测量状态，每个测量值提供了四组：UFA低或UFA高和AFA低或AFA高。UFA-高BMI组比两个低BMI组更胰岛素抵抗（p < 0.04），但AFA-高BMI组没有。相反，高UFA组的血浆甘油三酯和收缩压高于所有其他组（均p < 0.04）。当以体脂为特征时，两个高百分比（%）体脂组的空腹[胰岛素]高于低百分比（%）体脂组（p < 0.03），[总胆固醇]和[LDL胆固醇]高于UFA-低百分比（%）体脂组（p < 0.05）。高UFA组的收缩压和舒张压高于所有其他组（至少p < 0.03）。当以腰围为特征的组时，观察到类似的模式;然而，当前的身高状态没有影响。这些数据表明，“胎儿起源”的慢性疾病表型的表达是不依赖于出生体重单独，但其与随后的脂肪积累的相互作用，虽然没有达到的高度，在这个队列的年轻人。
We examined whether associations between low birthweight and adult chronic cardio-metabolic disease were dependent upon birthweight alone, or on interactions with BMI, fat accumulation either generally or abdominally, or attained height in young South African adults. Blood pressure (BP), lipids, glucose tolerance, insulin sensitivity and secretion (homeostasis model) were measured in 20-year-olds (n=132) born at full term and with birthweights on or below the tenth centile (underweight for gestational age [UFA]) or between the 25th and 75th centiles for gestational age (appropriate weight for gestational age, [AFA]). Sex-specific median measurements of BMI, waist circumference, percentage body fat and height defined current anthropometric status, providing four groups for each measure: UFA-low or UFA-high and AFA-low or AFA-high. The UFA-high BMI group was more insulin-resistant than both low BMI groups (p < 0.04), but not the AFA-high BMI group. In contrast, plasma triglycerides and systolic BP were higher in the UFA-high than in all other groups (all p < 0.04). When characterised by body fatness, both high percentage (%) body fat groups had higher fasting [insulin] than low percentage (%) body fat groups (p < 0.03), and higher [total cholesterol] and [LDL cholesterol] than the UFA-low percentage (%) body fat group (p < 0.05). The UFA-high group had higher systolic and diastolic BP than all other groups (all at least p < 0.03). A similar pattern was observed when groups were characterised by waist circumference; however, current height status had no effect. These data indicate that the "fetal origins" expression of the chronic disease phenotype is not dependent on birthweight alone, but on its interaction with subsequent fat accumulation, though not on attained height, in this cohort of young adults.