Resilience to social stress coincides with functional DNA methylation of the Crf gene in adult mice
Resilience to social stress coincides with functional DNA methylation of the Crf gene in adult mice
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DOI：
10.1038/nn.2642
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发表时间：
2010-11-01
影响因子：
25
通讯作者：
Chen, Alon
中科院分区：
文献类型：
--
作者：
Elliott, Evan;Ezra-Nevo, Gili;Chen, Alon
DNA甲基化调节基因转录，并已被认为编码源自早期生活压力的精神病理学。我们发现甲基化调节Crf（也称为Crh）基因的表达，成年小鼠的慢性社会压力诱导该基因组区域的长期去甲基化。去甲基化仅在显示社交回避和Crf位点特异性敲低的失败小鼠亚组中观察到，这减弱了应激诱导的社交回避。
DNA methylation regulates gene transcription and has been suggested to encode psychopathologies derived from early life stress. We found that methylation regulated the expression of the Crf (also known as Crh) gene and that chronic social stress in adult mice induced long-term demethylation of this genomic region. Demethylation was observed only in the subset of defeated mice that displayed social avoidance and site-specific knockdown of Crf attenuated the stress-induced social avoidance.