Further cytologic and histologic studies of bladder lesions in workers exposed to para-aminodiphenyl: progress report.
Further cytologic and histologic studies of bladder lesions in workers exposed to para-aminodiphenyl: progress report.
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接触对氨基二苯的工人膀胱病变的进一步细胞学和组织学研究：进展报告。
DOI：
10.1093/jnci/43.1.233
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发表时间：
1969
期刊：
影响因子：
--
通讯作者：
R. Kelly
中科院分区：
文献类型：
--
作者：
L. Koss;M. Melamed;R. Kelly
这是对503名男性意外暴露于一种强效膀胱癌物质对氨基二苯基（xenylamine）的长期研究的第三次间隔报告。迄今为止，35名男性经组织学证实为膀胱癌。尿沉渣的细胞学研究表明，接触后，在疾病过程中可能观察到三个不同的时期：1)细胞学和临床阴性期，持续数年；2)在没有临床疾病的情况下有一段细胞学异常期；3)细胞学和临床癌期。第二阶段膀胱活检的组织学研究表明，非乳头状癌通常是异常细胞的来源。对13例男性非乳头状原位癌的随访研究报道。到目前为止，这些男性中有7人患了浸润性膀胱癌。4、尿沉渣仍显示提示癌症的细胞学异常，但尚未有癌症的临床证据。2例患者病变活检后涂片恢复正常。后续工作还在继续。在一些接触者中，可疑的细胞学异常会自发消失，通常在几年的随访后恢复到正常的细胞学模式。因此，一些较小的上皮病变可以明显地自发恢复正常。膀胱癌的临床病程，无论是暴露于氨基二苯后还是自发发生，均无明显差异。然而，膀胱非乳头状癌明显比子宫颈癌更具侵袭性。
This is the third interval report on a long-term study of 503 men accidentally exposed to a potent bladder carcinogen, para-amino-diphenyl (xenylamine). To date, 35 men developed histologically proved carcinoma of the bladder. Cytologic studies of urinary sediment suggested that, after exposure, three distinct periods may be observed in the course of the disease: 1) a period of cytologic and clinical negativity, lasting several years; 2) a period of cytologic abnormalities in the absence of clinical disease; 3) a period of cytologic and clinical carcinoma. Histologic studies of bladder biopsies obtained during the second period disclosed that nonpapillary carcinomain situis usually the source of abnormal cells. Follow-up studies on a group of 13 men with nonpapillary carcinomain situ ab initioare reported. To date, invasive carcinoma of the bladder developed in 7 of these men. In 4, the urinary sediment still shows cytologic abnormalities suggestive of cancer, but there is no clinical evidence of cancer as yet. In 2 men, the smears became normal after biopsies of the lesion. This follow-up continues. In some exposées, suspicious cytologic abnormalities disappeared spontaneously, reverting to normal cytologic pattern, often after several years of follow-up. Thus, some of the lesser epithelial lesions may apparently spontaneously revert to normal. There is no obvious difference between the clinical course of carcinomas of the bladder, whether they have followed exposure top-aminodiphenyl or have occurred spontaneously. However, nonpapillary carcinomain situof the bladder is apparently a much more aggressive lesion than carcinomain situof the uterine cervix.