Saturation biopsy protocol enhances prediction of pT3 and surgical margin status on prostatectomy specimen
Saturation biopsy protocol enhances prediction of pT3 and surgical margin status on prostatectomy specimen
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DOI：
10.1007/s00345-006-0134-7
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发表时间：
2006-12-01
影响因子：
3.4
通讯作者：
de la Taille, Alexandre
中科院分区：
文献类型：
--
作者：
Descazeaud, Aurelien;Rubin, Mark;de la Taille, Alexandre
为了提高前列腺癌的检出率，我们开发了一种21例饱和活检程序（SBP）。在接受该方案的650名患者中，150名患有临床局限性前列腺癌并接受了根治性前列腺切除术。在SBP、SBP的六分仪分量（SC）和SBP的非六分仪分量（NSC）中评估肿瘤阳性核心的数量。pT3组SBP、SC和NSC上肿瘤阳性的核心数量显著高于pT2组（均P < 0.001），手术切缘阳性（PSM）组显著高于无PSM组（均P < 0.001）。当比较SBP与NSC和SC的曲线下面积时，SBP对pT3和PSM的预测准确度高于NSC和SC。多因素分析显示，SC和NSC是根治性直肠癌切除术中pT3和PSM的独立预测因素。
A 21-samples saturation biopsy procedure (SBP) was developed in order to improve prostate cancer detection rate. Out of 650 patients who underwent this protocol, 150 had a clinically localized prostate cancer and underwent a radical prostatectomy. The number of cores positive for tumor was assessed in the SBP, and also in the sextant component of the SBP (SC) and in the non-sextant component of the SBP (NSC). Numbers of cores positive for tumor on SBP, SC, and NSC were significantly higher in pT3 group versus pT2 (P < 0.001 each) and in positive surgical margins (PSM) group versus no PSM (P < 0.001 each). When comparing area under the curve obtained from SBP with those obtained from NSC and SC, the SBP showed higher accuracy than the NSC and the SC for the prediction of pT3 and PSM. On multivariate analyses, SC and NSC were independent predictors of pT3 and PSM on radical prostatectomy.