Changes in plasma and erythrocyte omega-6 and omega-3 fatty acids in response to intravenous supply of omega-3 fatty acids in patients with hepatic colorectal metastases.
Changes in plasma and erythrocyte omega-6 and omega-3 fatty acids in response to intravenous supply of omega-3 fatty acids in patients with hepatic colorectal metastases.
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DOI：
10.1186/1476-511x-12-64
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发表时间：
2013-05-07
影响因子：
4.5
通讯作者：
Dennison AR
中科院分区：
文献类型：
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作者：
Al-Taan O;Stephenson JA;Spencer L;Pollard C;West AL;Calder PC;Metcalfe M;Dennison AR
二十碳五烯酸 (EPA) 和二十二碳六烯酸 (DHA) 是功能上最重要的 omega-3 多不饱和脂肪酸 (PUFA)。口服这些脂肪酸会增加其在血浆和细胞膜中的水平，但通常会消耗 omega-6 PUFA 花生四烯酸 (ARA) 和亚油酸。这导致脂质介质产生模式改变，变成促炎性较低的模式。我们研究了短期静脉注射 omega-3 PUFA 是否可以改变肝结直肠转移患者血浆和红细胞中 EPA、DHA、ARA 和亚油酸的水平。 20 名患者被随机接受 72 小时全肠外营养输注，其中含有（治疗组）或不含（对照组）omega-3 PUFA。在输注结束前以及停止输注后 5 至 12 天（平均 9 天）的多个时间点测量血浆磷脂酰胆碱 (PC) 和红细胞中的 EPA、DHA、ARA 和亚油酸。治疗组血浆 PC EPA 和 DHA 以及红细胞 EPA 增加，血浆 PC 和红细胞亚油酸减少，效果在输注后期最为明显。经过 5-12 天的清除后，血浆 PC、红细胞 EPA 和亚油酸均恢复至基线水平。清洗后血浆 PC DHA 仍高于基线。静脉注射 omega-3 PUFA 会导致血浆 PC 中的 EPA 和 DHA 以及红细胞中的 EPA 快速增加。这些发现表明，输注 omega-3 PUFA 可用于诱导快速效果，尤其是在针对炎症方面。 http://www.clinicaltrials.gov 标识符 NCT00942292
Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are functionally the most important omega-3 polyunsaturated fatty acids (PUFAs). Oral supply of these fatty acids increases their levels in plasma and cell membranes, often at the expense of the omega-6 PUFAs arachidonic acid (ARA) and linoleic acid. This results in an altered pattern of lipid mediator production to one which is less pro-inflammatory. We investigated whether short term intravenous supply of omega-3 PUFAs could change the levels of EPA, DHA, ARA and linoleic acid in plasma and erythrocytes in patients with hepatic colorectal metastases. Twenty patients were randomised to receive a 72 hour infusion of total parenteral nutrition with (treatment group) or without (control group) omega-3 PUFAs. EPA, DHA, ARA and linoleic acid were measured in plasma phosphatidylcholine (PC) and erythrocytes at several times points up to the end of infusion and 5 to 12 days (mean 9 days) after stopping the infusion. The treatment group showed increases in plasma PC EPA and DHA and erythrocyte EPA and decreases in plasma PC and erythrocyte linoleic acid, with effects most evident late in the infusion period. Plasma PC and erythrocyte EPA and linoleic acid all returned to baseline levels after the 5–12 day washout. Plasma PC DHA remained elevated above baseline after washout. Intravenous supply of omega-3 PUFAs results in a rapid increase of EPA and DHA in plasma PC and of EPA in erythrocytes. These findings suggest that infusion of omega-3 PUFAs could be used to induce a rapid effect especially in targeting inflammation. http://www.clinicaltrials.gov identifier NCT00942292