Concentration of perfluorohexyl bromide in dog plasma and selected tissues.
Concentration of perfluorohexyl bromide in dog plasma and selected tissues.
复制标题
狗血浆和选定组织中全氟己基溴的浓度。
DOI：
10.1002/jps.2600701104
复制
发表时间：
1981
影响因子：
3.8
通讯作者：
J. Edelson
中科院分区：
文献类型：
--
作者：
M. Scrime;J. Edelson
比格犬接受单次全氟己基溴给药，剂量为30.2 g/kg po或3.8 g/kg肠内给药。终末消除相的表观一级血浆半衰期约为口服给药后8小时，大于肠道给药后8小时。组织分析显示，腹膜内给药后1周，腹部脂肪中化合物的平均浓度最高。通过任一给药途径给药后4周，1只犬的腹部脂肪水平可检出。
Beagle dogs received single perfluorohexyl bromide doses, either 30.2 g/kg po or 3.8 g/kg intratracheally. The apparent first-order plasma half-life during the terminal elimination phase was approximately 8 hr after oral treatment and greater than 8 hr after intratracheal administration. Tissue analysis showed the highest mean concentration of the compound in abdominal fat 1 week after intratracheal administration. One dog had detectable levels in abdominal fat 4 weeks after treatment by either administration route.