No evidence of sexual transmission of Kaposi's sarcoma herpes virus in a heterosexual South African population-猫眼课题宝

DOI：

10.1097/qad.0b013e3282f46582

发表时间：

2008-02-19

期刊：

AIDS

影响因子：

3.8

通讯作者：

中科院分区：

医学2区

文献类型：

作者：

Malope, Babatyi I.;MacPhail, Patrick;Whitby, Denise

背景资料：卡波西肉瘤疱疹病毒（KSHV）的传播与男性发生性关系的男性明显与性风险因素，但KSHV的异性传播的证据是矛盾的。方法：血清获得2103南非个人（862矿工，95性工作者，731名女性和415名男性乡镇居民，平均年龄33.2岁; +/- 10.1）。所有血清均检测KSHV裂解性K8.1和潜伏性Orf 73、HIV、淋球菌、单纯疱疹病毒2型（HSV-2）、梅毒和衣原体抗体。社会，人口统计学和高危性行为的信息，我连接到实验室数据，以评估危险因素，表示为比值比（95%置信区间）KSHV.Results：总体KSHV和HIV的患病率分别为47.5%和40%，分别（P=0.43）。性工作者感染HIV的危险性最高，其次是女性居民和矿工，男性居民感染HIV的危险性最低（P < 0.001）。HSV-2感染的流行率很高（66%），其他性传播感染（STI）的流行率较低，但仍然很高（6-8%）。不同居住人群KSHV感染率差异无统计学意义（P > 0.05）。KSHV与性传播感染和性行为指标均无相关性（P > 0.05）。结论：性工作者HIV感染和性传播感染的模式提示该人群高危性行为的发生率较高。缺乏与高风险的性行为，特别是在性工作者，并与任何性病的标志物强烈表明，性模式并没有发挥重要作用，在南非人口的KSHV传播。(c)2008年威科健康垂直酒吧Lippincott威廉姆斯&威尔金斯

Background: The transmission of Kaposi's sarcoma herpes virus (KSHV) in men who have sex with men is clearly associated with sexual risk factors, but evidence of heterosexual transmission of KSHV is conflicting.Methods: Sera were obtained from 2103 South African individuals (862 miners, 95 sex workers, 731 female and 415 male township residents; mean age 33.2 years; +/- 10.1). All sera were tested for antibodies to KSHV lytic K8.1 and latent Orf73, HIV, gonococcus, herpes simplex virus type 2 (HSV-2), syphilis and chlamyclia. Information on social, demographic and high-risk sexual behavior was I inked to laboratory data, to evaluate risk factors, expressed as odds ratios (95% confidence interval) for KSHV.Results: Overall KSHV and HIV prevalences were 47.5 and 40%, respectively (P=0.43). The risk of HIV infection was highest in sex workers then female residents and miners, compared with male residents (P < 0.001). HSV-2 infection was highly prevalent (66%) and lower, but still substantial, prevalences (6-8%) were observed for other sexually transmitted infections (STI). No significant difference in KSHV infection was observed among the residential groups (P > 0.05). KSHV was not associated with any of the STI or any measures of sexual behavior (P > 0.05).Conclusion: The pattern of HIV and STI in sex workers suggests high rates of high-risk sexual behavior in this population. The lack of association with high-risk sexual behavior, particularly in sex workers, and with any markers of STI strongly suggest that the sexual mode does not play a significant role in KSHV transmission in this South African population. (c) 2008 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins

No evidence of sexual transmission of Kaposi's sarcoma herpes virus in a heterosexual South African population

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