Disassembling adherens junctions: breaking up is hard to do
Disassembling adherens junctions: breaking up is hard to do
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DOI：
10.1016/j.tcb.2004.11.002
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发表时间：
2005-01-01
影响因子：
19
通讯作者：
D'Souza-Schorey, C
中科院分区：
文献类型：
--
作者：
D'Souza-Schorey, C
上皮细胞在胚胎发育期间和疾病状态如肿瘤转移中调节其与邻近细胞的接触。细胞间粘附连接（AJ）是一种特殊的亚顶端结构，是细胞粘附的主要介质.它们的分解与细胞-细胞接触的丧失和迁移潜力的获得相关。通过基因转录调节AJ组分的表达可以决定细胞间粘附接触的稳定性，并且越来越多的证据表明，细胞过程如膜运输和细胞骨架重塑的协调调节也可以导致AJ的有效溶解。转录后机制的研究，其中粘附相互作用的调节响应于生长因子和/或发展线索，开辟了新的途径，研究细胞间粘附在发展过程中和疾病。
Epithelial cells regulate their contacts with neighboring cells during embryonic development and in disease states such as tumor metastasis. The intercellular adherens junctions (AJs) are specialized subapical structures that function as principle mediators of cellcell adhesion. Their disassembly correlates with a loss of cell-cell contact and an acquisition of migratory potential. Regulation of the expression of AJ components by gene transcription can dictate the stability of intercellular adhesive contacts, and accruing evidence indicates that the coordinated regulation of cellular processes such as membrane trafficking and cytoskeletal remodeling can also result in the effective dissolution of AJs. Studies of the posttranscriptional mechanisms by which adhesive interactions are regulated in response to growth factors and/or developmental cues have opened new avenues for investigating cell-cell adhesion during development and in disease.