Thermosensitive neurons of the diagonal band in rats: relation to wakefulness and non-rapid eye movement sleep.
Thermosensitive neurons of the diagonal band in rats: relation to wakefulness and non-rapid eye movement sleep.
复制标题
大鼠对角线带的热敏神经元：与觉醒和非快速动眼睡眠的关系。
DOI：
10.1016/s0006-8993(96)01452-7
复制
发表时间：
1997
期刊：
影响因子：
2.9
通讯作者：
Szymusiak,R
中科院分区：
文献类型：
--
作者：
Alam,MN;McGinty,D;Szymusiak,R
本文观察了12只自由活动大鼠Broca斜角带(DBB)神经元的温度敏感性。在151个神经元中，37个(25%)神经元符合温度敏感性标准，包括17个温敏神经元(WSNs)和20个冷敏神经元(CSNS)。通过1~3个睡眠-觉醒周期记录WSNs和CSNS的自发放电频率。WSNs和CSNS在清醒和非快速眼动(NREM)睡眠时的放电不同。在17个WSN中，有10个在非快速眼动睡眠时较清醒时放电频率增加(非快速眼动/觉醒放电比率，≥为1.2)。在20个CSN中，14个在非快速眼动睡眠状态下的放电较清醒时慢(非快速眼动/觉醒放电比率，≤为0.8)。在WSNs和CSNS中，在觉醒-NREM转变时，放电率的变化先于脑电变化。这些结果支持一种假说，即睡眠相关的WSN的激活和觉醒相关的CSN的失活在NREM睡眠的开始和调节中起作用。
The thermosensitivity of the neurons in the diagonal band of Broca (DBB) was studied in 12 freely moving rats by determining responses to local cooling or warming with a water perfused thermode. Of 151 neurons studied, 37 (25%) neurons met the criterion for thermosensitivity including 17 warm-sensitive (WSNs) and 20 cold-sensitive neurons (CSNs). The spontaneous discharge rates of WSNs and CSNs were recorded through 1–3 sleep-waking cycles. The discharge of WSNs and CSNs during waking and non-rapid eye movement (NREM) sleep were different. Of 17 WSNs, 10 exhibited increased discharge rates during NREM sleep as compared with waking (NREM/Wake discharge ratio, ≥ 1.2). Of 20 CSNs, 14 discharged more slowly during NREM sleep as compared with waking (NREM/Wake discharge ratio, ≤ 0.8). In both WSNs and CSNs, changes in discharge rate preceded EEG changes at the waking-NREM transition. These results support a hypothesis that the activation of sleep-related WSNs and the deactivation of wake-related CSNs play a role in the onset and regulation of NREM sleep.