CELLULAR-IMMUNITY IN DEPRESSED, CONDUCT DISORDER, AND NORMAL ADOLESCENTS - ROLE OF ADVERSE LIFE EVENTS
CELLULAR-IMMUNITY IN DEPRESSED, CONDUCT DISORDER, AND NORMAL ADOLESCENTS - ROLE OF ADVERSE LIFE EVENTS
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DOI：
10.1097/00004583-199406000-00008
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发表时间：
1994-06-01
影响因子：
13.3
通讯作者：
RYAN, ND
中科院分区：
文献类型：
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作者：
BIRMAHER, B;RABIN, BS;RYAN, ND
目的：确定青少年抑郁症患者是否存在细胞免疫紊乱，并研究所检测到的免疫学变化是抑郁症特有的还是对应激的一般反应。方法：选取20例抑郁症患者、17例伴品行障碍的非抑郁症患者和17例正常青少年为研究对象。受试者接受了DSM-III-R临床访谈和改良版科丁顿生活事件检查表的评估。采集血样，测定总白色血细胞、淋巴细胞亚群、自然杀伤细胞活性、淋巴细胞对植物血凝素的增殖反应和血浆皮质醇水平。结果：总的来说，在任何细胞免疫测量中没有显著的组间差异。在所有效应细胞-靶细胞比率中，自然杀伤细胞活性与过去一年和一生中的不良生活事件显著负相关。控制诊断和社会经济地位也得到了类似的结果。年龄、性别、种族、睡眠、营养、吸烟、月经周期或皮质醇对任何免疫学变量均无显著影响。结论：在这个青少年样本中，我们发现，独立于诊断和社会经济地位，不良生活事件的增加与自然杀伤细胞活性低有关。
Objective: To determine whether adolescents with major depressive disorder have disturbances in their cellular immunity and to study whether the immunological changes detected are specific to depression or are general responses to stress. Method: Twenty subjects with major depressive disorder, 17 nondepressed subjects with conduct disorder, and 17 normal adolescents were recruited. Subjects were assessed with a clinical interview for DSM-III-R and a modified version of the Coddington Life Events Checklist. Blood samples were drawn for total white blood cells, lymphocytes subsets, natural killer cell activity, lymphocyte proliferation response to phytohemagglutinin, and cortisol plasma levels. Results: Overall, there were no significant between-group differences in any of the cellular immune measurements. Natural killer cell activity was significantly negatively correlated with past year and lifetime adverse life events across all effector-target cell ratios. Controlling for diagnoses and socioeconomic status yielded similar results. There were no significant effects of age, sex, race, sleep, nutrition, cigarette use, menstrual cycle, or cortisol on any of the immunological variables. Conclusions: In this sample of adolescents, we found that independent of the diagnoses and socioeconomic status, increases in adverse life events were associated with low natural killer cell activity.