Tissue polarimetry: concepts, challenges, applications, and outlook
Tissue polarimetry: concepts, challenges, applications, and outlook
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DOI：
10.1117/1.3652896
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发表时间：
2011-11-01
影响因子：
3.5
通讯作者：
Vitkin, I. Alex
中科院分区：
文献类型：
--
作者：
Ghosh, Nirmalya;Vitkin, I. Alex
偏振测量在各种形式的透明介质中有着悠久且成功的历史。受其生物医学潜力的推动，偏振方法在生物组织评估中的应用近来也受到了相当多的关注。具体而言，偏振可被用作一种有效的工具来区分多次散射光（作为一种选通机制），以提高对比度并改善组织成像分辨率。此外，组织的固有偏振特性包含大量具有潜在生物医学重要性的形态和功能信息。然而，在像组织这样的复杂随机介质中，由于多次散射以及许多散射和偏振事件的同时发生所带来的众多复杂性，在精确测量以及组织偏振信号分析方面都带来了巨大的挑战。为了实现偏振方法在组织成像以及特性描述/诊断方面的潜力，许多研究人员因此正在寻求针对这些挑战的创新解决方案。在这篇综述文章中，我们总结了与组织中的偏振光方法相关的这些以及其他问题。具体来说，我们讨论了偏振光基础、斯托克斯 - 米勒形式体系、偏振测量方法、混浊介质中的偏振光建模、在组织成像中的应用、偏振结果量化的逆分析、在定量组织评估中的应用等。（C）2011年光电仪器工程师协会（SPIE）。[DOI: 10.1117/1.3652896]
Polarimetry has a long and successful history in various forms of clear media. Driven by their biomedical potential, the use of the polarimetric approaches for biological tissue assessment has also recently received considerable attention. Specifically, polarization can be used as an effective tool to discriminate against multiply scattered light (acting as a gating mechanism) in order to enhance contrast and to improve tissue imaging resolution. Moreover, the intrinsic tissue polarimetry characteristics contain a wealth of morphological and functional information of potential biomedical importance. However, in a complex random medium-like tissue, numerous complexities due to multiple scattering and simultaneous occurrences of many scattering and polarization events present formidable challenges both in terms of accurate measurements and in terms of analysis of the tissue polarimetry signal. In order to realize the potential of the polarimetric approaches for tissue imaging and characterization/diagnosis, a number of researchers are thus pursuing innovative solutions to these challenges. In this review paper, we summarize these and other issues pertinent to the polarized light methodologies in tissues. Specifically, we discuss polarized light basics, Stokes-Muller formalism, methods of polarization measurements, polarized light modeling in turbid media, applications to tissue imaging, inverse analysis for polarimetric results quantification, applications to quantitative tissue assessment, etc. (C) 2011 Society of Photo-Optical Instrumentation Engineers (SPIE). [DOI: 10.1117/1.3652896]