Cancer mortality and environmental exposure to DDE in the United States
Cancer mortality and environmental exposure to DDE in the United States
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DOI：
10.2307/3454288
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发表时间：
2000-01-01
影响因子：
10.4
通讯作者：
Zahm, SH
中科院分区：
文献类型：
--
作者：
Cocco, P;Kazerouni, N;Zahm, SH
为了探讨DDE（主要和最持久的DDT衍生物）在癌症病因学中的作用，我们研究了1968年美国22个州人群样本的脂肪DDE水平与1975年至1994年间多发性骨髓瘤、非霍奇金淋巴瘤（NHL）和乳腺癌、子宫体癌、肝癌和胰腺癌年龄调整死亡率的相关性。按性别和人种进行单独分析。回归模型中的协变量包括人均收入、大城市居民百分比和人口密度。在白人中，肝癌死亡率随着脂肪DDE水平的增加而显着增加，但在非洲裔美国人中则不然。胰腺癌和多发性骨髓瘤之间没有相关性。乳腺癌死亡率与白色和非洲裔美国妇女的脂肪DDE水平呈负相关。在白色妇女中也观察到子宫癌的显著负相关，而在非裔美国人和白人（男性和女性）和非裔美国妇女中未观察到相关性。胰腺癌、多发性骨髓瘤、NHL、乳腺癌和子宫癌的结果不支持与DDT衍生物DDE过去的脂肪水平相关的假设。多变量分析证实了大多数发现。在白人中观察到的肝癌与DDE之间的关联，特别是鉴于暴露于DDT的实验室动物中肝肿瘤的发生，值得进一步调查。
To explore the role of DDE, the major and most persistent DDT derivative, in cancer etiology, we examined the association of the 1968 adipose DDE levels of population samples from 22 U.S. states with age-adjusted mortality rates between 1975 and 1994 for multiple myeloma; non-Hodgkin lymphoma (NHL); and cancer of the breast, corpus uteri, liver, and pancreas. Separate analyses were conducted by gender and race. Covariates in the regression models included average per-capita income, percent metropolitan residents, and the population density. Liver cancer mortality increased significantly with adipose DDE levels in both sexes among whites, but not among African Americans. No association was observed for pancreatic cancer and multiple myeloma. Breast cancer mortality was inversely correlated with adipose DDE levels among both white and African American women. Significant inverse correlations were also observed for uterine cancer among white women, whereas no association was observed for African Americans and for NHL among whites (men and women) and African American women. The results for pancreatic cancer, multiple myeloma, NHL, breast cancer, and uterine cancer did not support the hypothesis of an association with past adipose levels of the DDT derivative DDE. The multivariate analysis confirmed most findings. The association between liver cancer and DDE observed among whites, particularly in view of the occurrence of hepatic neoplasms in laboratory animals exposed to DDT, warrants further investigation.