Flexible electronic/optoelectronic microsystems with scalable designs for chronic biointegration
Flexible electronic/optoelectronic microsystems with scalable designs for chronic biointegration
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DOI：
10.1073/pnas.1907697116
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发表时间：
2019-07
期刊：
影响因子：
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通讯作者：
E. Song;Chia-Han Chiang;Rui Li;Xin Jin;Jianing Zhao;Mackenna Hill;Yu Xia;Lizhu Li;Yuming Huang
中科院分区：
文献类型：
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作者：
E. Song;Chia-Han Chiang;Rui Li;Xin Jin;Jianing Zhao;Mackenna Hill;Yu Xia;Lizhu Li;Yuming Huang
新兴类别的柔性电子系统旨在接口到人体的软组织作为生物电子形式的医学的基础，与功能，可以补充那些传统的制药方法。这项工作建立了生物集成微系统类别的工程科学，其中包括数万个微器件的组装，这些微器件在薄的柔性聚合物基底上互连成功能网络，其区域接近人脑。详细的体外研究表明，这些系统能够提供复杂的电子和光电功能，并具有数十年的稳定，生物安全操作。这些结果定义了在生物电子学领域具有广泛实用性的概念和技术方法。利用与消费电子行业相关的关键材料和制造技术的灵活生物相容性电子系统在生物医学和生物研究中具有广泛应用的潜力。本研究报告了这种类型的技术的可扩展方法，其中薄的微米级设备组件集成到互连阵列中的柔性聚合物基板上，以提供多模态，高性能的操作能力，作为密切耦合的生物界面。具体来说，这里总结的材料选择和工程方案是各种异质集成系统的基础。按比例缩放的示例包括源自晶片源的> 32，000个硅微芯片和无机微尺度发光二极管，所述晶片源以可变的间距间隔和填充因子分布在聚合物膜上的大面积上，在全器官尺度尺寸（例如，超过150 cm 2的人脑）下。体外研究和模拟生物流体中的加速测试，以及基础过程的理论模拟，可以对关键材料方面产生定量的见解。结果表明，这些系统能够以生物安全，稳定的方式运行，预计寿命为几十年，没有泄漏电流或性能降低。这些组合概念的多功能性表明适用于许多类别的生物集成半导体器件。
Significance Emerging classes of flexible electronic systems designed to interface to soft tissues of the human body serve as the foundations for bioelectronic forms of medicine, with capabilities that can complement those of traditional pharmaceutical approaches. This work establishes the engineering science of categories of biointegrated microsystems that include assemblies of tens of thousands of microdevices interconnected into functional networks on thin flexible polymer substrates with areas that approach those of the human brain. Detailed in vitro studies suggest the ability of these systems to provide sophisticated electronic and optoelectronic function with stable, biologically safe operation for many decades. The results define concepts and technological approaches with widespread utility in the field of bioelectronics. Flexible biocompatible electronic systems that leverage key materials and manufacturing techniques associated with the consumer electronics industry have potential for broad applications in biomedicine and biological research. This study reports scalable approaches to technologies of this type, where thin microscale device components integrate onto flexible polymer substrates in interconnected arrays to provide multimodal, high performance operational capabilities as intimately coupled biointerfaces. Specificially, the material options and engineering schemes summarized here serve as foundations for diverse, heterogeneously integrated systems. Scaled examples incorporate >32,000 silicon microdie and inorganic microscale light-emitting diodes derived from wafer sources distributed at variable pitch spacings and fill factors across large areas on polymer films, at full organ-scale dimensions such as human brain, over ∼150 cm2. In vitro studies and accelerated testing in simulated biofluids, together with theoretical simulations of underlying processes, yield quantitative insights into the key materials aspects. The results suggest an ability of these systems to operate in a biologically safe, stable fashion with projected lifetimes of several decades without leakage currents or reductions in performance. The versatility of these combined concepts suggests applicability to many classes of biointegrated semiconductor devices.