The role of transient receptor potential channels in respiratory symptoms and pathophysiology.
The role of transient receptor potential channels in respiratory symptoms and pathophysiology.
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DOI：
10.1007/978-94-007-0265-3_50
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发表时间：
2011
影响因子：
--
通讯作者：
M. McAlexander;T. Taylor-Clark
中科院分区：
文献类型：
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作者：
M. McAlexander;T. Taylor-Clark
瞬时受体电位通道构成了功能多样性无与伦比的离子通道超家族。最近采用药理学和遗传学方法的研究表明，这些通道广泛分布在呼吸道内，它们可能在机制上将有害刺激物暴露和炎症与气道反射敏感性升高、病理重塑和气流受限联系起来。在此，我们总结了这个快速扩展领域的最新技术，除了强调瞬时受体电位通道在气道感觉神经中的已知作用外，还强调了它们在非兴奋性细胞中的作用。
The Transient Receptor Potential channels constitute a superfamily of ion channels that is unmatched in its functional diversity. Recent research employing pharmacological and genetic methods has demonstrated that these channels are widely distributed within the respiratory tract, where they may mechanistically link noxious irritant exposures and inflammation to heightened airway reflex sensitivity, pathological remodeling and airflow limitation. Herein, we summarize the state of the art in this rapidly expanding area, emphasizing the known roles of Transient Receptor Potential channels in airway sensory nerves in addition to highlighting their roles in non-excitable cells.