Dodecaborate Conjugates Targeting Tumor Cell Overexpressing Translocator Protein for Boron Neutron Capture Therapy
Dodecaborate Conjugates Targeting Tumor Cell Overexpressing Translocator Protein for Boron Neutron Capture Therapy
复制标题
DOI：
10.1021/acsmedchemlett.1c00377
复制
发表时间：
2022-01-13
影响因子：
4.2
通讯作者：
Kirihata, Mitsunori
中科院分区：
文献类型：
--
作者：
Hattori, Yoshihide;Ishimura, Miki;Kirihata, Mitsunori
我们开发了一种新型的闭合十二硼酸根([B12H11](2-))阴离子转位蛋白(TSPO)配体作为硼的载体，用于硼中子俘获治疗。该化合物具有很高的水溶性，可以将硼输送到在乳腺癌细胞中高表达的TSPO。我们描述了一种基于十二硼酸基的吡唑并嘧啶的合成和体外评价。
We developed novel closo-dodecaborate ([B12H11](2-)) anion-containing translocator protein (TSPO) ligand as a boron carrier for boron neutron capture therapy. This compound shows high water solubility and can deliver boron to TSPO highly expressed in breast cancer cells. We describe the synthesis and in vitro evaluation of a dodecaborate-based pyrazolopyrimidine.