Nonspatial determinants of electrograms in guinea pig ventricle.
Nonspatial determinants of electrograms in guinea pig ventricle.
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豚鼠心室电描记图的非空间决定因素。
DOI：
10.1152/ajpcell.1981.240.3.c148
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发表时间：
1981
期刊：
影响因子：
--
通讯作者：
Arnsdorf,MF
中科院分区：
文献类型：
--
作者：
Holland,RP;Arnsdorf,MF
理论认为细胞外记录电位（epsilon）是由空间和非空间因素决定的。空间因素包括具有不同跨膜电压（Vm）的区域之间的边界以及边界与细胞外电极的关系。非空间因素包括跨边界的Vm[跨膜电位梯度（TPG）]和电导率项（C σ）。由于难以将非空间因素与空间决定因素区分开来，对非空间因素的实验研究很少。我们的模型使空间因子保持恒定，允许同时记录epsilon和Vm，并允许跨边界操纵Vm和C σ。Epsilon和TPG与[K+] 0、[Na+] 0、温度、传导、刺激率或早产和缺氧的变化具有可预测性。在TPG不变的情况下，epsilon可能受到缺氧和代谢性中毒引起的C σ变化的影响。非空间决定因素对epsilon的影响可以用电路类比来模拟。在使用心电图测量作为缺血指标的研究中，必须考虑非空间决定因素。
Theory states that the extracellularly recorded potential (epsilon) is determined by spatial and nonspatial factors. Spatial factors include the boundary between areas with different transmembrane voltages (Vm) and the relationship of the boundary to the extracellular electrode. Nonspatial factors include the Vm across the boundary [transmembrane potential gradient (TPG)] and a conductivity term (C sigma). Few studies have investigated the nonspatial factors experimentally due to the difficulty in separating the nonspatial from the spatial determinants. Our model rendered the spatial factors constant, permitted the simultaneous recording of epsilon and Vm, and allowed the manipulation of Vm and C sigma across the boundary. Epsilon and the TPG were related predictably with changes in [K+]o, [Na+]o, temperature, conduction, stimulus rate or prematurity, and hypoxia. In the presence of a constant TPG, epsilon could be affected by a change in C sigma caused by hypoxia and a metabolic poison. The effects of the nonspatial determinants on epsilon could be modeled using electrical circuit analogues. Nonspatial determinants must be considered in studies using electrocardiographic measures as an index of ischemia.