Regulation and deregulation of mRNA translation during myeloid maturation.
Regulation and deregulation of mRNA translation during myeloid maturation.
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DOI：
10.1016/j.exphem.2010.10.011
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发表时间：
2011-02
影响因子：
2.6
通讯作者：
Khanna-Gupta, Arati
中科院分区：
文献类型：
--
作者：
Khanna-Gupta, Arati
真核细胞中的基因表达在许多水平上受到调节，包括基因组DNA转录成mRNA、mRNA的核质输出以及输出的mRNA通过核糖体翻译成细胞质中的蛋白质。表观遗传学和转录因子在发育中的中性粒细胞中与基因表达控制相关的作用多年来已被充分记录和赞赏。大量关于转录因子在骨髓生物学中所起作用的信息有助于我们理解正常和异常的中性粒细胞发育。然而，髓样细胞成熟中mRNA翻译的调控研究得少得多。更好地了解髓系基因表达的翻译控制可能为正常和异常髓系成熟提供重要的见解。.本文综述了我们目前对髓系基因表达在mRNA翻译水平上的调控的认识。
Gene expression in the eukaryotic cell is regulated at a number of levels including transcription of genomic DNA into mRNA, nucleocytoplamic export of mRNA, and translation of the exported mRNA into proteins in the cytoplasm by ribosomes. The role played by epigenetics and transcription factors associated with the control of gene expression in the developing neutrophil has been well documented and appreciated over the years. A wealth of information on the role played by transcription factors in myeloid biology has contributed to our understanding of both normal and abnormal neutrophil development. However, the regulation of mRNA translation in myeloid cell maturation is much less well-studied. A better understanding of the translational control of myeloid gene expression may provide important insights into both normal and abnormal myeloid maturation. . This review summarizes our current understanding of the regulation of myeloid gene expression at the mRNA translational level.
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