Pronounced hypothermic synergy between systemic baclofen and NOS inhibitor.
Pronounced hypothermic synergy between systemic baclofen and NOS inhibitor.
复制标题
全身性巴氯芬和 NOS 抑制剂之间具有明显的低温协同作用。
DOI：
10.1016/j.ejphar.2004.08.049
复制
发表时间：
2004
期刊：
影响因子：
--
通讯作者：
Tallarida,RonaldJ
中科院分区：
文献类型：
--
作者：
Rawls,ScottM;Baron,DavidA;Gomez,Teresa;Jacobs,Kyle;Tallarida,RonaldJ
大鼠全身注射巴氯芬(腹腔注射)。单独或与L同名。巴氯芬(1-7.5 mg/kg，ip)引起剂量依赖性体温过低。L-NAME(50 mg/kg，ip)是无效的。对于联合用药，L的名字增加了巴氯芬的相对效力(F=10.77，p<；0.05)，表明乘性相互作用和协同作用。目前的数据揭示了一氧化氮合酶(NOS)和巴氯芬诱导的体温下降之间令人惊讶和显著的相互作用。
Baclofen was administered to rats systemically (intraperitoneal, i.p.) by itself or with l-NAME. Baclofen (1–7.5 mg/kg, i.p.) evoked dose-dependent hypothermia. l-NAME (50 mg/kg, i.p.) was ineffective. For combined administration, l-NAME increased the relative potency of baclofen (F=10.77, p<0.05), indicating multiplicative interaction and synergism. The present data reveal a surprising and significant interaction between nitric oxide synthase (NOS) and baclofen-induced hypothermia.