Role of MMP-1 1G/2G promoter gene polymorphism on the development of prostate cancer in the Turkish population
Role of MMP-1 1G/2G promoter gene polymorphism on the development of prostate cancer in the Turkish population
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DOI：
10.1159/000109715
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发表时间：
2007-01-01
影响因子：
1.6
通讯作者：
Koksal, Vedat
中科院分区：
文献类型：
--
作者：
Albayrak, Selami;Canguven, Oender;Koksal, Vedat
目的：探讨土耳其人群中基质金属蛋白酶-1(MMP1)基因启动子1G/2G多态性与前列腺癌易感性的关系。材料和方法：采用聚合酶链式反应-限制性片段长度多态性分析方法，对55例前列腺癌患者和43例健康人的基质金属蛋白酶-1基因启动子区进行了基因分型。结果：前列腺癌患者1G/2G等位基因频率与对照组相似(P均<0.05)。与1G/1G基因相比，2G/2G或与1G/2G基因的组合均不能显著改变前列腺癌的发病风险和转移状况。此外，按吸烟状况和前列腺癌家族史分层的患者之间的基因频率没有显著差异。结论：至少在土耳其人群中，基质金属蛋白酶-1启动子的2G等位基因可能不会改变前列腺癌的发生风险，也不能作为预测前列腺癌转移潜能的可能标记物。版权所有c 2007 S.Karger AG，巴塞尔。
Introduction: To investigate the association of 1G/2G polymorphism in matrix metalloproteinase-1 (MMP-1) promoter with susceptibility to prostate carcinoma in the Turkish population. Materials and Methods: MMP-1 promoter polymorphism was genotyped by PCR-RFLP analysis in 55 prostate cancer patients and 43 healthy controls. Results: The frequency of 1G/2G genotypes in prostate cancer patients was similar to that of the controls (all p values were > 0.05). Compared with the 1G/1G genotype, neither the 2G/2G nor a combination with the 1G/2G genotype significantly modified the risk of developing prostate cancer and metastasis status. In addition, the frequencies of genotypes were not significantly different among patients stratified by smoking status and family history of prostate cancer. Conclusions: The 2G allele of the MMP-1 promoter polymorphism might not modify the risk of prostate cancer development and might not be used as a putative marker to predict the potential of metastasis in this cancer type, at least in the Turkish population. Copyright c 2007 S. Karger AG, Basel.