Abnormal functional connectivity in resting state contribute to the weaker emotional sensitivity to reward in depression
Abnormal functional connectivity in resting state contribute to the weaker emotional sensitivity to reward in depression
复制标题
静息状态下的功能连接异常会导致抑郁症患者对奖励的情绪敏感性减弱
DOI：
10.1080/13803395.2022.2156480
复制
发表时间：
2022-12-24
影响因子：
2.2
通讯作者：
Liu，Zhiyuan
中科院分区：
文献类型：
--
作者：
Li，Shuang;Guo，Xiuyan;Liu，Zhiyuan
前言抑郁症是一种以情感领域的扭曲为特征的最常见的精神疾病。采用静息态功能磁共振成像（rs-fMRI）技术，探讨奖赏情绪敏感性的神经机制，方法选取28名抑郁症状加重组（LD组）和28名低抑郁症状组（LD组）的受试者，采用问卷调查法，对LD组和低抑郁症状组的情绪反应性进行比较，结果发现，LD组和低抑郁症状组受试者的情绪反应性差异不显著（P> 0.05）。艾德）组。在rs-fMRI扫描后，被试被要求完成一个连续的冒险任务，在这个任务中，他们可能会遇到奖励和loss. Results-FC之间的腹侧纹状体（VS）和额下回（IFG）的静息态功能连接（rs-FC）与LD组的情绪敏感性奖励。与LD组相比，在艾德组的参与者表现出较弱的情绪敏感性奖励和较强的rs-FC VS和前额叶regions.ConclusionsThe目前的研究强调，功能之间的连接VS和IFG在静息状态下与情绪敏感性奖励低抑郁症状的个人。然而，抑郁症状加重的个体在静息状态下表现出VS和IFG之间的功能连接改变，这可能导致他们对奖励的情感敏感性较弱。
IntroductionDepression is one of the most prevalent mental diseases characterized by distortions in the affective sphere. By using resting-state functional magnetic resonance imaging (rs-fMRI) technique, the current study aimed to investigate neural mechanisms associated with emotional sensitivity to reward, which represented the variation of emotional responsiveness as the degree of reward changing in individuals with depressive symptoms.MethodsWe recruited 28 participants in elevated depressive symptoms (LD) group and 28 demographic-matched participants in low depressive symptoms (ED) group. After the rs-fMRI scan, participants were asked to complete a sequential risk-taking task, in which they might encounter both reward and loss.ResultsThe resting-state functional connectivity (rs-FC) between ventral striatum (VS) and inferior frontal gyrus (IFG) was associated with the emotional sensitivity to reward in LD group. Compared with LD group, participants in ED group showed weaker emotional sensitivity to reward and stronger rs-FC between VS and prefrontal regions.ConclusionsThe current study highlighted that the functional connectivity between VS and IFG in the resting state was related to the emotional sensitivity to reward in individuals with low depressive symptoms. However, individuals with elevated depressive symptoms exhibited altered functional connectivity between VS and IFG in the resting state, which might contribute to their weaker emotional sensitivity to reward.