Cortical and Subcortical Projections from Granular Insular Cortex Receiving Orofacial Proprioception
Cortical and Subcortical Projections from Granular Insular Cortex Receiving Orofacial Proprioception
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DOI：
10.1016/j.neuroscience.2018.07.047
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发表时间：
2018-09
期刊：
影响因子：
3.3
通讯作者：
Yumi Tsutsumi;Y. Tachibana;F. Sato;T. Furuta;Haruka Ohara;A. Tomita;Masatoshi Fujita;M. Moritani;A. Yoshida
中科院分区：
文献类型：
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作者：
Yumi Tsutsumi;Y. Tachibana;F. Sato;T. Furuta;Haruka Ohara;A. Tomita;Masatoshi Fujita;M. Moritani;A. Yoshida
我们最近发现，来自闭颌肌梭（JCMS）的本体感觉信号通过大鼠腹侧后内侧丘脑核（VPM）的尾腹内侧边缘（VPMcvm）传递到与次级体感皮层（dGIrvs2）的头端部分相邻的颗粒岛叶皮质的喙腹背侧部分。然而，目前尚不清楚 JCMS 本体感受信息随后从 dGIrvs2 传递到哪个皮质或皮质下结构。为了测试这个问题，我们将顺行示踪剂生物素化右旋糖胺注射到电生理学鉴定的 dGIrvs2 中，并分析了大鼠中标记的轴突末端的分布概况。标记的终端以同侧为主分布。在大脑皮质中，它们见于初级和次级体感皮质、外侧和内侧无颗粒皮质以及背外侧眶皮质。在基底神经节中，它们存在于尾壳核、伏隔核的核心部分、苍白球外侧核、丘脑底核以及黑质致密部和网状部。在中央杏仁核和扩展杏仁核（前连合后肢间质核和终纹床核外侧分裂的囊旁部分）中也观察到了它们。在丘脑中，它们可见于网状核、腹内侧核、核心VPM、腹后核的小细胞部分、卵圆旁中央核、后核的内侧和三角形部分、未定带以及VPMcvm。这些数据表明 JCMS 本体感受信息通过 dGIrvs2 传输到情感“边缘”区域以及感觉运动区域。
We have recently revealed that the proprioceptive signal from jaw-closing muscle spindles (JCMSs) is conveyed to the dorsal part of granular insular cortex rostroventrally adjacent to the rostralmost part of secondary somatosensory cortex (dGIrvs2) via the caudo-ventromedial edge (VPMcvm) of ventral posteromedial thalamic nucleus (VPM) in rats. However, it remains unclear to which cortical or subcortical structures the JCMS proprioceptive information is subsequently conveyed from the dGIrvs2. To test this issue, we injected an anterograde tracer, biotinylated dextranamine, into the electophysiologically identified dGIrvs2, and analyzed the resultant distribution profiles of labeled axon terminals in rats. Labeled terminals were distributed with an ipsilateral predominance. In the cerebral cortex, they were seen in the primary and secondary somatosensory cortices, lateral and medial agranular cortices and dorsolateral orbital cortex. In the basal ganglia, they were found in the caudate putamen, core part of accumbens nucleus, lateral globus pallidus, subthalamic nucleus, and substantia nigra pars compacta and pars reticulata. They were also observed in the central amygdaloid nucleus and extended amygdala (the interstitial nucleus of posterior limb of anterior commissure and the juxtacapsular part of lateral division of bed nucleus of stria terminalis). In the thalamus, they were seen in the reticular nucleus, ventromedial nucleus, core VPM, parvicellular part of ventral posterior nucleus, oval paracentral nucleus, medial and triangular parts of posterior nucleus, and zona incerta as well as the VPMcvm. These data suggest that the JCMS proprioceptive information through the dGIrvs2 is transmitted to the emotional ‘limbic’ regions as well as sensorimotor regions.