Circulating Serum Myonectin Levels in Obesity and Type 2 Diabetes Mellitus
Circulating Serum Myonectin Levels in Obesity and Type 2 Diabetes Mellitus
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DOI：
10.1055/a-0896-8548
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发表时间：
2021-07-01
影响因子：
1.8
通讯作者：
Niu, Wen-Yan
中科院分区：
文献类型：
--
作者：
Li, Zhu;Yang, Yan-Ling;Niu, Wen-Yan
目的肌粘连蛋白是肌细胞因子之一，作为一种潜在的治疗肥胖及其相关疾病的新策略，如2型糖尿病（T2 DM）本研究的目的是调查非糖尿病和2型糖尿病患者的循环血清肌连接素水平，并阐明2型糖尿病患者血清肌连接素水平与代谢参数之间的可能关系。本研究招募了100名T2 DM患者和100名年龄和性别匹配的健康对照者。临床特征，血液生化，和循环肌连接蛋白水平测定酶联免疫吸附试验。结果循环肌连接蛋白水平显着降低T2 DM与对照组相比。肥胖非糖尿病对照组血清肌连结蛋白水平显著低于瘦非糖尿病对照组。在糖尿病患者中，血清肌联蛋白浓度与体重指数（BMI）、总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL-C）、C反应蛋白（CRP）、血红蛋白A1 c（HbA 1c）、空腹胰岛素（Fins）、胰岛素抵抗稳态模型评估（HOMA-IR）、内脏脂肪面积和皮下脂肪面积呈显著负相关。多元逐步回归分析显示，BMI、LDL-C、TG、HOMA-IR和内脏脂肪是T2 DM患者和肥胖者血中myonectin浓度降低的主要独立预测因子。此外，血清肌粘连蛋白水平与T2 DM的代谢标志物相关。这些数据表明，肌粘连蛋白可能是预测肥胖和T2 DM发展的有用标志物。
Objective Myonectin is one of the myokines and has gained interest as a potential new strategy to combat obesity and its associated disorders, such as type 2 diabetes mellitus (T2DM).The objective of this study was to investigate circulating serum myonectin levels in nondiabetes and T2DM and elucidate possible relationships between serum myonectin levels and metabolic parameters in patients with T2DM.Design A total of 362 Chinese patients with T2DM and 100 age- and sex-matched healthy controls were recruited in this study. Clinical characteristics, blood biochemistry, and circulating myonectin levels were measured by enzyme-linked immunosorbent assay.Results Circulating myonectin levels were significantly decreased in T2DM compared with controls. Obese nondiabetic controls had significantly lower serum myonectin levels compared with lean nondiabetic controls. In diabetic patients, serum myonectin concentrations were significantly negatively correlated with body mass index (BMI), total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), C-reactive protein (CRP), hemoglobin A1c (HbA1c), fasting insulin (Fins), the homeostatic model assessment of insulin resistance (HOMA-IR), visceral fat area, and subcutaneous fat area. After adjusting for covariates, multivariate stepwise regression analysis demonstrated that BMI, LDL-C, TG, HOMA-IR, and visceral fat were the main independent predictors of low serum myonectin concentrations.Conclusions Circulating myonectin levels were decreased in T2DM patients and in obese subjects. Moreover, serum myonectin levels were correlated with metabolic markers of T2DM. These data suggest that myonectin may be a useful marker in predicting the development of obesity and T2DM.