Inverse Relationship between Serum Osteocalcin Levels and Visceral Fat Area in Chinese Men
Inverse Relationship between Serum Osteocalcin Levels and Visceral Fat Area in Chinese Men
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中国男性血清骨钙素水平与内脏脂肪面积呈负相关
DOI：
10.1210/jc.2012-2906
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发表时间：
2013-01-01
影响因子：
5.8
通讯作者：
Jia, Weiping
中科院分区：
文献类型：
--
作者：
Bao, Yuqian;Ma, Xiaojing;Jia, Weiping
目的：血清骨钙素水平与体脂分布的关系尚不清楚。本研究旨在探讨中国男性血清骨钙素水平与内脏脂肪面积（VFA）的关系。设计：用电化学发光免疫分析法测定1768名中国男性（22-75岁）血清总骨钙素水平。通过磁共振成像定量VFA。对血清骨钙素水平与临床参数进行相关性分析。从整个研究人群中选择葡萄糖耐量和体重指数正常的受试者，进行亚组分析以确认相关性。结果：血清骨钙素水平升高，肥胖、收缩压、血糖、胰岛素抵抗指数、甘油三酯、游离脂肪酸、c反应蛋白等人体测量指标均呈下降趋势（P < 0.05）。50-75（骨钙素水平：16.18-19.88 ng/ml）和75 （>= 19.89 ng/ml）百分位组的VFA低于25 (
Objective: The relationship between serum osteocalcin levels and body fat distribution remains unclear. This study aimed to investigate the association between serum osteocalcin levels and visceral fat area (VFA) in Chinese men.Design: Total serum osteocalcin levels were measured in 1768 Chinese men (22-75 yr old) by electrochemiluminescence immunoassay. VFA was quantified via magnetic resonance imaging. Correlation analyses were carried out for serum osteocalcin levels and clinical parameters. Subgroup analysis was carried out to confirm the correlations using subjects with normal glucose tolerance and normal body mass index chosen from the entire study population.Results: Increased serum osteocalcin levels were accompanied by a decreasing trend in all anthropometric indices of obesity, systolic blood pressure, blood glucose, insulin resistance index, triglycerides, free fatty acid, and C-reactive protein levels (all P < 0.05). The 50-75th (osteocalcin level: 16.18-19.88 ng/ml) and 75th (>= 19.89 ng/ml) percentile groups had lower VFA than the 25th (