Hyperimmune globulin in pregnancy for the prevention of congenital cytomegalovirus disease
Hyperimmune globulin in pregnancy for the prevention of congenital cytomegalovirus disease
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DOI：
10.1080/14787210.2017.1398081
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发表时间：
2017-01-01
影响因子：
5.7
通讯作者：
Nigro, Giovanni
中科院分区：
文献类型：
--
作者：
Nigro, Giovanni
前言：巨细胞病毒(CMV)是发达国家最常见和最严重的先天性感染原因，因为它可以在初次和反复母体感染后感染胎儿，并可通过感染的儿童传播多年。内容涉及：关于CMV特异性高免疫球蛋白(HIG)预防先天性CMV感染和疾病的动物和人类妊娠研究。商业HIG是由具有高抗CMV抗体亲和力和效价的选定捐赠者的血浆制成的。专家评论：目前可用的实验和临床研究和病例报告支持在妊娠期间输注HIG预防先天性CMV疾病的可能的有效性和安全性。应通过多中心随机研究扩大对预防或治疗HIG潜在疗效的认识，这可能有利于CMV筛查的实施。同时，如果超声检查显示胎儿有损伤迹象，或羊水中检测到CMV，应建议患者选择HIG治疗。
Introduction: Cytomegalovirus (CMV) is the most common and serious cause of congenital infections in developed countries since it is capable of infecting the fetus after both primary and recurrent maternal infection, and can be spread for years by infected children.Areas covered: Animal and human pregnancy studies about the prevention of congenital CMV infection and disease by CMV-specific hyperimmune globulin (HIG). Commercial HIG is manufactured from the plasma of selected donors with high anti-CMV antibody avidity and titers.Expert commentary: Currently available experimental and clinical studies and case reports support the possible effectiveness and safety of HIG infusions in pregnancy for the prevention of congenital CMV disease. The knowledge about the potential efficacy of preventive or therapeutic HIG administration should be enlarged by multi-center randomized studies, which may be favored by the implementation of CMV screening. Meanwhile, if ultrasound examinations show signs of fetal injury, or CMV is detected in the amniotic fluid, the patients should be advised about the possible option of HIG therapy.