Retrovirus envelope glycoproteins.
Retrovirus envelope glycoproteins.
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DOI：
10.1007/978-3-642-75218-6_7
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发表时间：
1990
影响因子：
--
通讯作者：
Eric Hunter;R. Swanstrom
中科院分区：
文献类型：
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作者：
Eric Hunter;R. Swanstrom
可复制逆转录病毒的包膜糖蛋白复合物由两种多肽组成，即外部糖基化亲水多肽（SU）和跨膜蛋白（TM），它们在病毒体表面形成球状或球状刺突。这两种多肽都在envgene中编码，并以多聚蛋白前体的形式合成，该多聚蛋白前体在其转运至细胞表面期间被蛋白水解裂解。虽然这些蛋白质不是组装包膜病毒颗粒所必需的，但它们通过识别和结合特异性受体（SU）以及介导病毒和细胞膜（TM）的融合在病毒复制周期中发挥关键作用：因此缺乏包膜糖蛋白的病毒颗粒是无感染性的。
The envelope glycoprotein complex of replication competent retroviruses is comprised of two polypeptides, an external, glycosylated, hydrophilic polypeptide (SU) and a membrane-spanning protein (TM), that form a knob or knobbed spike on the surface of the virion. Both polypeptides are encoded in theenvgene and are synthesized in the form of a polyprotein precursor that is proteolytically cleaved during its transport to the surface of the cell. While these proteins are not required for the assembly of enveloped virus particles, they do play a critical role in the virus replication cycle by recognizing and binding to specific receptors (SU) and by mediating the fusion of viral and cell membranes (TM): virus particles lacking envelope glycoproteins are thus noninfectious.