Dietary factors protective against breast cancer in japanese premenopausal and postmenopausal women
Dietary factors protective against breast cancer in japanese premenopausal and postmenopausal women
复制标题
DOI：
10.1002/ijc.11373
复制
发表时间：
2003-11-01
影响因子：
6.4
通讯作者：
Tajima, K
中科院分区：
文献类型：
--
作者：
Hirose, K;Takezaki, T;Tajima, K
由于尚未详细阐明可能导致日本乳腺癌发病率相对较低的日本饮食成分，因此使用爱知癌症中心（HERPACC）基于医院的表皮研究项目的数据进行了一项关于绝经状态的病例参考研究。总共纳入了2，385例乳腺癌病例，并招募了19，013名被确认为无癌症的女性作为参考组。采用多元Logistic回归分析确定优势比（OR）和95%可信区间（95%CI）。在绝经前后的妇女中，大量摄入牛奶和黄绿色蔬菜（绿色多叶蔬菜、胡萝卜和南瓜）可降低患病风险。日本饮食的保护作用在绝经后妇女中比绝经前妇女更为突出。对于绝经后乳腺癌，鱼类摄入量（每周5次或以上vs每月少于3次）的校正OR为0.75（95% CI 0.57-0.98，P趋势= 0.01）。增加水果摄入量也可显著降低绝经后乳腺癌的风险（OR = 0.61，95%CI 0.41-0.91）。因此，传统的日本饮食因素可能会防止乳腺癌的发展，特别是在绝经后妇女中。(C)2003 Wiley-Liss，Inc.
Since components of the Japanese diet that might be responsible for the relatively low breast cancer incidence rates observed in Japan have not been clarified in detail, a case-referent study with reference to menopausal status was conducted using data from the hospital-based epiderniologic research program at Aichi Cancer Center (HERPACC). In total, 2,385 breast cancer cases were included, and 19,013 women, confirmed as free of cancer, were recruited as the reference group. Odds ratios (ORs) and 95% confidence intervals (95% Cls) were determined by multiple logistic regression analysis. There were reductions in risk associated with high intake of milk and green-yellow vegetables (green leafy vegetables, carrots and pumpkins) among both pre- and postmenopausal women. The protective effects of the Japanese diet were more prominent among postmenopausal than premenopausal women. The adjusted OR of fish consumption (S or more times per week vs. fewer than 3 times per month) was 0.75 (95% Cl 0.57-0.98, P-trend = 0.01) for postmenopausal breast cancer. A significant decrease in postmenopausal breast cancer risk was also observed for increasing intake of fruit (OR = 0.61, 95% Cl 0.41-0.91). Thus, traditional Japanese dietary factors may protect against breast cancer development, especially among postmenopausal women. (C) 2003 Wiley-Liss, Inc.