Molecular Systems Biology Peer Review Process File Dynamics of Protein Noise Can Distinguish between Alternate Sources of Gene-expression Variability Transaction Report-猫眼课题宝

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Abhyudai Singh;B. Razooky;R. D. Dar;L. Weinberger

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(Note: With the exception of the correction of typographical or spelling errors that could be a source of ambiguity, letters and reports are not edited. The original formatting of letters and referee reports may not be reflected in this compilation.) Thank you again for submitting your work to Molecular Systems Biology. We have now heard back from two of the three referees who agreed to evaluate your manuscript, and have decided to render a decision now to avoid further delay. As you will see from the reports below, the referees generally found the method proposed in this work potentially interesting. Both independently indicated, though, that additional experimental work would be needed to rigorously validate the ability of this method to distinguish transcription and translational noise, before it would be appropriate for publication in Molecular Systems Biology. Each reviewer makes specific recommendations for additional experiments that could potentially help address their concerns. If you feel you can satisfactorily deal with the points listed by the referees, you may wish to submit a revised version of your manuscript. Please attach a covering letter giving details of the way in which you have handled each of the points raised by the referees. A revised manuscript will be once again subject to review and you probably understand that we can give you no guarantee at this stage that the eventual outcome will be favorable. When preparing your revised work, the raw intensity data for Fig. 3, requested by Reviewer #1, can be provided as "figure source data". Please see our Instructions of Authors for more details on preparation and formatting of figure source data

Molecular Systems Biology Peer Review Process File Dynamics of Protein Noise Can Distinguish between Alternate Sources of Gene-expression Variability Transaction Report

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