Synthesis of Chiral Trifluoromethyl-Substituted Hydrazines via Pd-Catalyzed Asymmetric Hydrogenation and Reductive Amination
Synthesis of Chiral Trifluoromethyl-Substituted Hydrazines via Pd-Catalyzed Asymmetric Hydrogenation and Reductive Amination
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Pd催化不对称氢化和还原胺化合成手性三氟甲基取代肼
DOI：
10.1021/acscatal.5b01641
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发表时间：
2015-10-01
期刊：
影响因子：
12.9
通讯作者：
Zhou, Yong-Gui
中科院分区：
文献类型：
--
作者：
Chen, Zhang-Pei;Hu, Shu-Bo;Zhou, Yong-Gui
以Pd催化的N-酰基和N-芳基腙的不对称氢化反应为基础，发展了一种合成环状和线型手性三氟甲基取代肼的有效方法，收率高达97%ee，并成功地实现了三氟甲基取代酮与肼的还原胺化反应.
An efficient approach toward the synthesis of cyclic and linear chiral trifluoromethyl substituted hydrazines was developed by Pd-catalyzed asymmetric hydrogenation of both N-acyl and N-aryl hydrazones in excellent yields and up to 97% ee. A successful reductive amination between trifluormethyl substituted ketones and hydrazines was also achieved.